BOOST NAD+ FOR HEALTHY AGEING
with Nicotinamide Riboside, Apigenin and Vitamin B3
NAD+ is the co-enzyme that is essential to creating energy in each one of your body's 37 trillion cells. But NAD+ declines as you get older – typically by about 50% by your late 50s.
Nicotinamide Riboside supplements are proven in multiple studies to increase NAD+ and help you counter that energy decline.
Maintaining energy in your cells is central to the health of every single organ – but none more so than your heart and brain.
Your mitochondria cannot function without NAD+.
Your 37 trillion cells are continuously using and then regenerating energy. That happens thousands of times a day in each of your mitochondria – the tiny power plants in every cell that convert food and oxygen to energy.
It’s difficult to believe, but this activity is so frequent and intense that it is calculated you produce your body weight of the energy molecule ATP – a day!! Link to reference
NAD+ is essential to power the many hundreds of vital processes that ensure your body and brain work normally.
Taking Nicotinamide Riboside (NR) is proven – in over 100 pre-clinical and human clinical studies – to safely help raise NAD+ levels, which decline as you get older. NR therefore improves energy production and supports healthy ageing.
Approved health benefits of nicotinamide riboside chloride, as a form of niacin (vitamin B3), are that it contributes to:
♦ The reduction of tiredness and fatigue
♦ Normal energy-yielding metabolism
♦ The maintenance of normal skin
♦ Normal functioning of the nervous system
♦ Normal mucous membranes
♦ Normal psychological function
DOUBLE ACTION NAD+ BOOST
Maintaining NAD+ is a key to healthy ageing, because your NAD+ levels and your health are directly linked. And Nicotinamide Riboside increases NAD+.
But as you age, more and more NAD+ is consumed before it can properly generate energy. So, you tire more often and more quickly.
A natural plant nutrient called Apigenin (found in chamomile and parsley) can powerfully inhibit that NAD+ from reducing.
We even add the Nicotinamide form of Vitamin B3, which also contributes to normal energy-yielding metabolism and reduction of tiredness and fatigue.
Uni-Vite’s combination of Nicotinamide Riboside + Apigenin + Vitamin B3 is a unique ‘boost and block’ approach to healthy ageing based on the latest longevity science.
BACKED BY SCIENCE
NAD+ is essential for the healthy functioning of your mitochondria, for DNA repair and immune function
Nicotinamide Riboside, NAD+ and Apigenin have been featured in dozens of scientific journals and the media:
Nature Scientific Reports - Newsweek - Science Direct - Medline - National Library of Medicine - Medical Express - Biogerontology - Today’s Practitioner - Neurobiology - Diabetes - Longevity - Forbes
Link below to just some of the hundreds of scientific studies that led to this safe, new anti-ageing supplement.
SAFE AND EFFECTIVE
Nutrients approved by EFSA and FDA
Nicotinamide Riboside, Apigenin and Vitamin B3 as Nicotinamide have been approved as food supplements by the European Food Safety Authority (EFSA) and the US Food and Drug Administration (FDA).
Nicotine Riboside – but NOT Nicotinamide Mononucleotide (NMN) – has been classified as safe by the US FDA and as a safe Novel Food (NF) by the European Food Safety Agency, which the UK adheres to for supplements.
“The Panel concludes that [the NF Nicotinamide Riboside] is safe ... for the healthy adult population, excluding pregnant and lactating women, and that an intake of [the NF Nicotinamide Riboside] up to 230 mg/day is safe for pregnant and lactating women”.
Over 20 clinical studies have confirmed effectiveness and safety of Nicotinamide Riboside (NR). Here are just two.
Nature Communications: "NR raises NAD+ levels in 60 healthy men and women – ages 55-79" Link to reference
Cell Reports: "NR supplementation in aged subjects augments the skeletal muscle NAD+ metabolome. NR supplementation reduces levels of circulating inflammatory cytokines." Link to reference
In human studies, taking 1,000–2,000 mg per day of NR had no harmful effects. Link to reference
Numerous studies show that apigenin has multiple health benefits and a very high safety threshold. Some studies have used in excess of 1,000mg a day. Link to reference
Colin Rose, Senior Associate of the Royal Society of Medicine and Fellow of the Royal Society of Arts and the author of the 2020 book Delay Ageing, explains in a short video below how the science of NAD+ can help you stay healthier longer.
COLIN ROSE EXPLAINS NR+A
MORE ABOUT Nicotinamide Riboside, Apigenin and NAD+
NAD+ is a co-enzyme, meaning it acts as catalyst or helper for very many essential biological processes Link to reference, such as:
♦ Converting food into energy
♦ Repairing damaged DNA
♦ Strengthening the immune system and cellular defence
♦ Setting your body’s internal clock or circadian rhythm
However, the amount of NAD+ in your body naturally falls with age – typically by 50% in middle age.
Low NAD+ levels have been linked to ageing itself and health concerns like diabetes, heart disease, and Alzheimer’s disease. Conversely raising NAD+ levels has become a major target for healthy ageing.
Studies show that nicotinamide riboside raises blood NAD+ levels by as much as 250% and that it is more readily used by your body than other NAD+ precursors Link to reference. Nicotinamide riboside is found in trace amounts in cows’ milk, yeast and beer. But average intake from food sources is below 1 mg a day. Studies indicate that the level needed to counteract the decline in NAD+ production is above 200mg a day.
Broad health effects of NR include 'good' gene activation
Research until recently was mainly on animal models Link to reference, but has now been extended to humans. This body of research has found that raising NAD+ levels may not only help reverse signs of ageing, including muscle mass Link to reference, but can help lower the risk of many age related diseases, including cardio/heart issues.
In particular, improving NAD+ via Nicotinamide Riboside has been shown to increase the activity of a family of genes called sirtuins that are seen to improve lifespan in mammals Link to reference. Sirtuins are confirmed in human studies as helping repair damaged DNA Link to reference, reducing inflammation and ensuring normal brain function as we get older. Link to reference
Heart disease is still the world’s leading cause of death and linked strongly to ageing. Ageing blood vessels become thicker, stiffer and less flexible. In turn that leads to raised blood pressure levels.
In human trials, Nicotinamide Riboside was seen to raise NAD+ levels, help reduce stiffness in the aorta and lower systolic blood pressure in middle aged and older adults at risk of high blood pressure. Link to reference
Body clock effect?
NAD+ helps regulate your body’s internal clock, so taking Nicotinamide Riboside might help treat jet lag or sleep issues. Although clinical evidence is limited, it may be worth trying on your next long-haul flight. Link to reference
Apigenin is a natural phyto-nutrient found in many plant foods, but the highest concentrations are in chamomile, dried parsley and onions. Consequently, the average person’s intake is about 3-4 mg a day. The threshold level to affect NAD+ levels is 30mg a day.
Apigenin is an anti-inflammatory and known to offer a range of health benefits, including supporting heart and brain health. Therefore, it is now seen to be an important healthy anti-ageing supplement.
Let’s start, however, with why Apigenin should be combined with Nicotinamide Riboside to increase NAD+ levels.
Apigenin slows the loss of NAD+
If you look at this illustration of how NR enters the cell to create NAD+ you’ll also see a molecule called CD 38 on the surface of that cell.
CD 38 is an enzyme, which is a protein that accelerates chemical reactions.
CD 38 is used by cells to counteract inflammation. Because inflammation increases with age, the level of the CD 38 enzyme increases as you get older to combat this inflammation. But this then consumes more and more NAD+.
So, if we could help stop CD38 from depleting NAD+, this would be a second, indirect, but important way to improve available energy in our cells.
At the same time as you’ll be making more NAD+, you’ll also be using less.
Fortunately, we have discovered how to do that.
In the last decade, scientists have discovered that apigenin is the most potent, natural, way helps reduce the activity of CD 38. Link to reference.
Apigenin therefore helps prevent CD38 from consuming or depleting NAD+. This obviously supports the maintenance of NAD+ levels, which in turn conserves cellular energy levels, which in turn supports healthy ageing. Link to reference 1 and Link to reference 2 and Link to reference 3
Combining Apigenin with Nicotinamide Riboside is a twin anti-ageing strategy
So, by helping to reduce the consumption or drain on NAD+ (with apigenin) and simultaneously boosting the production of NAD+ (with NR) you can not only increase, but maintain, higher levels of NAD+ and hence cellular energy.
It’s a powerful, twin anti-ageing strategy that has been validated in clinical trials.
Finally, note that CD 38 activity is higher in obese people, while lower CD 38 activity appears to protect against obesity. Anecdotal evidence seems to show that people taking NR with apigenin find it easier to maintain weight.
Apigenin has other major benefits
There is some indication that apigenin may reduce anxiety levels in patients with anxiety disorder. This is probably because apigenin is particularly abundant in chamomile. Link to reference
Even more significantly, however, the Journal of the American Diabetes Association concluded that CD 38 inhibitors like apigenin have a positive effect on the pre-diabetic condition known as metabolic syndrome. Link to reference Apigenin helps this condition by improving insulin sensitivity, lowering blood sugar levels and thus – coupled with other lifestyle changes – may contribute to reducing the risk of diabetes.
Experimental studies suggest apigenin is an anti-cancer agent
An even more important potential benefit is that apigenin may help reduce the risk of cancer. This is an effect reported in multiple studies – which is why so many drug companies are investigating apigenin. Link to reference.
For these reasons, apigenin has been used as an adjunct to drugs in treating liver and other cancers Link to reference.
It has also been used in high doses to address a rare form of uterine cancer. Link to reference.
There is even some evidence that apigenin may help suppress the initiation of cancer itself. Link to reference
Myeloma Research reports that several CD 38 drugs are in use or in clinical trials for multiple myeloma. Link to reference
There is no suggestion that apigenin on its own can prevent or treat cancer – and the dose levels in these trials were considerably higher than in a nutraceutical supplement designed to increase NAD+. Nevertheless, a daily intake of apigenin seems a safe and positive element in an overall healthy ageing regime.
Brain health too
The role of apigenin would be to add support to other lifestyle actions known to reduce the risk of cognitive decline – including a largely plant based diet and exercise.
Boosting bio-availability of apigenin is important
One limitation of apigenin – in common with most polyphenols – is that its absorption and hence bioavailability is not high. The combination of piperine – a black pepper extract – with polyphenols does significantly improves their absorption. So, you would ideally consume apigenin together with a supplement like NutriShield which already contains piperine.
NutriShield also contains polyphenols from curcumin, grapeseed, green tea and betaine. They all act against inflammation – and lowering inflammation is another way in which less CD 38 is consumed.
Grapeseed extract is especially interesting because it down-regulates CD 38 and up-regulates the anti-ageing gene SIRT-1, which results in higher levels of NAD+. Link to reference
Promising evidence on cognitive health (Alzheimer's and dementia)
Age is the greatest risk factor for Alzheimer’s disease and dementia – and these are perhaps our most feared issues as we get older.
The brain is some 2% by weight of the body – but uses about 20% of its energy. So, maintaining cellular energy levels in the brain – and protecting neural mitochondria – is a logical healthy ageing strategy.
Evidence from MRI scans shows that NAD+ and mitochondrial function in the brain do decline over time, as they do in the body. Link to reference
The fact that NR can increase NAD+ levels – with Apigenin support – suggests the combination can be good for long term cognitive health. And that’s what pre-clinical studies (ie. animal studies) as reported in Neurobiology of Aging show.
Nicotinamide riboside supplementation is associated with fewer cognitive deficits, reduced production of beta-amyloid plaques, reduced levels of tau tangles, and fewer cell deaths. All these are hallmarks of cognitive decline. Link to reference A further study in 2022 supports the earlier findings that NR use can support a healthy brain. Link to reference
This is supported by separate animal studies that show that supplementation with NR might also benefit cognitive function by improving synaptic plasticity – essentially the ability of brain cells to connect and communicate with each other. Link to reference
Therefore, many researchers are concluding that NR may have a triple action protective effect on the central nervous system and against cognitive decline.
First, due to its positive effect on NAD+ levels and mitochondria, second by the activation of sirtuins, and third via its action against inflammation. Link to reference
There is no suggestion that NR can treat any brain illness, but we do know that the time to act preventatively is early – ideally before the onset of Mild Cognitive Impairment. This is supported by a review by the Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales. Link to reference
A 2020 study at the Centre for Healthy Brain Ageing summarises the research to-date:
“Oral nicotinamide riboside may represent a promising stratagem to improve cognitive decline during ‘normal’ ageing”. Link to reference
Two recent meta-reviews Link to reference and The Therapeutic Potential of Apigenin – PMC (nih.gov) concluded that apigenin could have a role in maintaining long term brain health, highlighting the:
“Therapeutic potential of apigenin, in particular its antioxidant activity and potential role as a neuroprotective agent”.
Your body prioritises its allocation of available energy – created through your metabolism. It will, above all, prioritise allocating energy for the brain and heart.
Even at rest, a body needs energy for hundreds of processes. These include breathing, heartbeat, brain activity, sending blood through the body, keeping hormone and temperature levels even, immune function and growing and repairing cells.
So, you may or may not feel much more muscle energy, but you can be sure that the extra energy from boosting NAD+ is translated into improvements that support your health.
BUY NR+A from just 50p a day
Combine with NutriShield Premium for a comprehensive anti-ageing strategy
This product is not intended to diagnose, treat, cure, or prevent any disease. Results may vary.
This information does not constitute medical advice and it should not be relied upon as such. Consult with your doctor before modifying your regular medical regime.