The energising supplement that helps repair DNA

The importance of NR in healthy ageing

I think I have failed to explain properly why our new Nicotinamide Riboside plus Apigenin – NR+A is such an important supplement, especially for brain and heart health. Maybe because the science is quite complicated.

Nicotinamide riboside (NR) is a form of Vitamin B3 that can be converted into a co-enzyme called NAD+, which is essential for hundreds of biological processes. NAD+ naturally declines with age, and increasing it can support healthy ageing.

I’ll start with a summary from independent research conducted over the last 5 years.

Anti-ageing health positives for Nicotinamide Riboside (NR)

Boosts NAD+ levels

NR is converted into a co-enzyme that is essential for hundreds of biological processes. That coenzyme is called NAD+ Nicotinamide Adenine Dinucleotide.

NAD+ levels naturally decline with age and increasing them can support overall health.

Supports healthy ageing

By raising NAD+ levels, NR has been shown to help

♦ reduce markers of ageing in tissues

♦ rejuvenate organ function

♦ revitalise old stem cells.

It activates other enzymes called sirtuins – known to be involved in improved longevity.

Enhances cellular energy production

NAD+ plays a critical role in converting food into energy, which can help maintain physical and mental energy levels and support metabolic processes.

Promotes brain health

NR has been shown to help protect brain cells and support cognitive function, potentially lowering the risk of neurodegenerative diseases like Alzheimer’s.

Improves heart health

Higher NAD+ levels are linked to better cardiovascular health, potentially reducing the risk of heart disease. A June 2024 NICE (the UK's National Institute for Health and Care Excellence) study showed significant improvements for people with peripheral artery disease. (NICE is not easy to convince!)

Ref. Nicotinamide riboside for peripheral artery disease: the NICE randomized clinical trial | Nature Communications

Helps DNA repair

NAD+ is indirectly involved in repairing damaged DNA, which is crucial for maintaining cellular health and helping preventing mutations.

Supports liver health

NR has been shown to support liver function and overall cellular metabolism.

The research base

A review of the literature in Nutrients (a highly regarded scientific journal) concluded:

"Accumulating evidence on NR's health benefits has validated its efficiency across numerous animal and human studies for the treatment of a number of cardiovascular, neurodegenerative and metabolic disorders."

Ref. Emerging Role of Nicotinamide Riboside in Health and Diseases - PMC (nih.gov)

Ref. Nicotinamide Riboside, a Promising Vitamin B3 Derivative for Healthy Aging and Longevity: Current Research and Perspectives - PMC (nih.gov)

Ref. Nicotinamide Riboside—The Current State of Research and Therapeutic Uses - PMC (nih.gov)

Formulating Nicotinamide Riboside plus Apigenin (NR+A)

Starting with Nicotinamide Riboside

NAD+ cannot be obtained from our diet. It must be made within our cells. Nicotinamide Riboside is one of the raw materials that the body uses to make NAD+. So, it is sometimes referred to as an “NAD+ precursor”.

Adding Apigenin

A protein called CD38 increases in our cells as we age and CD38 degrades NAD+. Apigenin is proven to inhibit CD38. Chamomile is one of the best natural sources of apigenin.

Apigenin boosts NAD+ by reducing the activity of the CD38 pathway that consumes NAD+.

A search for the scientific benefits of Apigenin also returns the following:

"Apigenin has antianxiety, antidepressant, and sleep-promoting effects, as well as supporting immune function and improving cognitive function.

"Apigenin was reported to suppress various human cancers in vitro and in vivo by multiple biological effects."

Why adding NR+A to NutriShield Premium is ideal

One of the main reasons that NAD+ levels decline with age is that more and more of this energy molecule is needed to counteract inflammation.

NutriShield Premium is a very powerful anti-inflammatory formula. So, when you take NutriShield, you use up less NAD+ in fighting inflammation. So more is available for cellular energy and DNA repair.

In addition, NutriShield Premium includes EGCG (epi-gallo-catechin-gallate) from green tea. EGCG inhibits a cellular enzyme called NNMT (nicotinamide N-methyltransferase). This enzyme NNMT increases with age, preventing NAD+ recycling in our cells. Inhibiting NNMT is known to increase NAD+ levels.

Summary

Your NAD+ levels decline because there is:

A decrease in NAD+ production. NAD+ production and recycling pathways are reduced with ageing.

AND

An increase in NAD+ consumption. Older cells are more subject to inflammation and consume more NAD+.

So, you need to restore NAD+ levels to support your cellular health. Which is the purpose of Uni-Vite’s NR +A.

NR+A is the best-priced NAD+ booster on the market

I have also failed to point out that Uni-Vite's NR+A is great value.

NR+A is £29.95 for 60 caplets ie. two months’ supply and therefore just 50p a day. [Or save £1 a pack by buying 2 packs.] The other main brand – at £49.95 for 30 caplets and therefore £1.66 a day – is over THREE times Uni-Vite's per day price.

You can buy Uni-Vite's NR+A here: Shop NR+A - NutriShield

----

Delay Ageing book explains the ageing process and how you can postpone it

Medical researchers agree that if you slow ageing, you also delay the onset of age-related disease. And we know that it’s not just nutrition. Sleep, reducing stress and cardio and strength exercise are also essential to longevity and ageing well.

My book Delay Ageing: Healthy to 100, published in 2020, explains the latest ageing science in an accessible way.

It’s been rated 5-star and I am sure you will get a lot of benefit from it, as so many have already.

Click here to go to the publisher's website where you can buy the printed book or Kindle version.