The secret of healthy longevity
Irina Papidakis is in her 60s, but she looks younger.
She is likely to live in robust good health well into her late 80s or early 90s. So will most of the people in Ikaria, the Mediterranean island where she lives.
Yuzo Nishimura is nearly 80. But he too looks less.
He lives in an area in Japan where many of his friends will also live, free of illness, to at least their early 90s.
They both live in what are called ‘Blue Zones’. Blue Zones are areas of the world where people are not just very long-lived – frequently to 100 – but where they also stay fit, mentally sharp and healthy.
We, in the West, may be living longer, but it’s how you live these years that really matters.
Too many suffer in their last decade from degenerative diseases like diabetes, arthritis, heart disease, cancer and dementia.
It doesn’t have to be like that.
Secrets of the world’s healthiest people
Irina and Yuzo’s principal ‘secret’ is their diet, the foods they eat. Their foods are of exceptionally high nutritional value – full of protective vitamins, minerals, trace elements, anti-oxidants, anti-inflammatories and other powerful plant nutrients.
But they are different diets. What if you could take the best elements of each?
Irina’s “Mediterranean Diet”
Irina eats what’s called the ‘Mediterranean Diet’. It corresponds with current dietary recommendations from the American Cancer Society and the British Heart Foundation.
In March 2018, The Journal of Gerontology published a meta-review which stated quite clearly:
“Consuming a traditional Mediterranean diet rich in minimally processed plant foods has been associated with a reduced risk of developing multiple chronic diseases and increased life expectancy.”
Yuzo’s Far-Eastern Diet
The same study acknowledged that certain other populations in Asia, notably parts of Japan, also achieved similar extended health and longevity results.
Diets here include oily fish, green tea, soy and the curry spice curcumin (turmeric). These foods and nutrients help contribute to Yuzo Nishimura’s ‘healthy longevity’.
A ‘super-boosted’ diet
All these other nutritional elements – which have also been subject to top-class published scientific research – should logically be combined to become a ‘super-boosted’ Mediterranean Diet.
Breakthrough research from the Leibniz Institute on Aging in 2017 also suggests that a ‘super-boosted’ diet should include optimum (not just RDA) levels of B complex vitamins, which are vital to prevent incorrect activation of genes.
Because although genes are a factor in health and longevity, a 2016 study clearly shows it is the impact of nutrition on the way genes are expressed that is the real key to health.
The simple way to ‘super-boost’ your diet
Dr Paul Clayton is the former Chair of the Forum on Food and Health at the Royal Society of Medicine. In researching his best-selling book “Health Defence”, he set out to determine exactly what foods and lifestyles could maintain genuinely good health into old age.
His conclusions are based on thousands of peer-reviewed research studies and clinical trials. And from analysis of the nutritional intakes in the regions of the world’s longest lived and healthiest people – the Blue Zones.
The result was not just a best-selling book, but an invitation to present his findings to a UK Parliamentary Select Committee.
Health Defence is over 600 pages long, and still available to buy in print or read online. But now Dr Clayton has also made his updated conclusions available as a simple to follow one-page plan.
The challenge of 10-a-day fruits and vegetables
But here’s the challenge. The American Cancer Society, the British Heart Foundation and other health experts call for up to 10 portions of fruits and vegetables a day. And 2-3 portions of oily fish (or other source of Omega 3 essential fats) a week.
Because only these high intakes of vitamins, minerals and plant-derived nutrients seem to confer enough protection to help prevent premature illness.
Illness doesn’t have to be age-related
The diseases we call ‘age-related’ are not actually related to the number of years of life – they are damage-related.
Damage to DNA, damage to mitochondria, damage to arteries and blood vessels, and a weakening of the immune system. It’s this accumulated damage that leads to accelerated ageing and illness.
If you prevent that damage with a protective diet, you give yourself the best possible chance of staying healthy.
Professor Partridge is the Director of the Institute of Healthy Ageing at University College London. She puts it well:
“What if getting older didn’t mean getting ill?”
Optimum nutrition helps you look younger, too
High blood levels of protective plant compounds – anti-oxidants, anti-inflammatories, vitamins, minerals and trace elements – are also linked to younger appearance. Because a healthy look on the outside is a function of healthy cells and active mitochondria on the inside.
A simple multi-vitamin A-Z isn’t enough
A 10-a-day fruit and vegetable diet is really hard to achieve in normal Western daily life – even for conscientious people. So many people take a nutritional supplement. But will it work?
The evidence is that a simple one-a-day vitamin and mineral pill, at merely RDA levels, is not enough – especially for older people (50+).
Because, after this age, people’s nutritional needs increase – at the very time that their ability to absorb and utilise vital nutrients starts to decrease.
RDAs are established at ‘just adequate’ levels to prevent deficiency diseases – like scurvy or rickets – not at optimised levels to help counteract accumulated damage.
Just ‘adequate’ is not optimum
All of which is why many doctors dismiss inexpensive, RDA based, A-Z supplements as largely ineffective. And that scepticism is supported by research – there is little evidence that multi-vitamins alone reduce the risk of heart disease or cancer.
That’s because they have been separated and isolated from other plant nutrients that make a Mediterranean or Far Eastern diet unquestionably healthy.
These nutrients are vital ‘co-factors’ for vitamins and minerals, enabling them to be absorbed properly by the body.
Combining the best of the best to ‘super-boost’ your nutrition
We have created a one-page simple guide that ensures you can eat the most protective foods for long term health.
It includes lifestyle advice on achievable activity targets and ways to improve mental well-being with mindfulness and relaxation.
It crystallises years of advice in recognised health newsletters from universities like Harvard, Tufts and Berkeley – as well as 35 years of research by Dr Paul Clayton.
The guide also recognises that there is a role for a comprehensive daily health supplement to ‘fill in the gaps’ so that you can achieve optimum nutrition every day.
An effective supplement needs to include the sort of co-factor plant nutrients found in the Blue Zones, not just vitamins and minerals.
To get all these nutrients day after day, from food alone, is a challenge – in terms of planning, cooking and even calories. Not the least, because our intensively-farmed soils are becoming less nutrient dense.
The following are plant micro-nutrients that research shows can make a real difference. Some help activate genes that promote health and others deactivate genes that threaten health. (You can click on any one for more information.)
12 Superfood Plant Nutrients
 Curcuminoids in turmeric |
 Catechins in green tea |
 Lutein carotenoids in leafy greens |
 Lycopene carotenoids in tomatoes |
 Beta carotene in carrots |
 Procyanidins in grapeseed |
 Soy isoflavones in eg. tofu |
 Zeaxanthin carotenoids in eg. spinach |
 Betaine in beets |
 CoEnzyme Q10 in eg. peanuts |
 Glucosamine made in the body, or in some foods like sweetcorn |
 Anthocyanidins in bilberries |
Essential vitamins, minerals and Omega 3 fats
 Essential vitamins and minerals at optimum, not just RDA levels |
 Omega 3 – high EPA/DHA |
The healthy eating/healthy ageing plan anyone can follow
You can download the one-page health plan based on Dr Clayton’s 35 years of research here.
We believe getting older does NOT have to mean getting ill. And that the primary focus of our healthcare system is unsustainable. It should be far more on prevention rather than cure.
NutriShield comprehensive supplement
You’ve probably heard that we should all “eat a rainbow” – have a variety of colours from different plant foods on your plate.
NutriShield is a daily comprehensive supplement, designed by Dr Paul Clayton. It contains a rainbow of ALL the protective bio-active plant micro-nutrients highlighted above, PLUS an optimum level of essential vitamins and minerals and Omega 3.
Go to NutriShield Premium here.
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Dr Paul Clayton designed NutriShield as a comprehensive health
supplement with OPTIMUM levels of 43 essential nutrients including standardised green tea extract, polyphenols and flavonoids from fruits, vegetables and other plants, Omega 3, betaine and soy isoflavones. See more detail elsewhere on this site or click on the button.
Dr Paul Clayton’s best-selling book Health Defence is available from bookstores or from Uni-Vite Healthcare here.
A free summary report and the opportunity to read the book online is available here.
See online here for delicious recipes from the Health Defence Cookbook incorporating healthy foods featuring in a Mediterranean Diet. 
REFERENCES
Health Benefits of the Mediterranean Diet: Metabolic and Molecular Mechanisms: Valeria Tosti, MD Beatrice Bertozzi, PhD Luigi Fontana, MD, PhD The Journals of Gerontology: Series A, Volume 73, Issue 3, 2 March 2018.
Human longevity: Genetics or Lifestyle? It takes two to tango Giuseppe Passarino, Francesco De Rango, and Alberto Montesanto; Immun Ageing. 2016; 13: 12.
https://www.cochrane.org/news/new-cochrane-health-evidence-challenges-belief-omega-3-supplements-reduce-risk-heart-disease
Omega-3 Fatty Acids and Depression: Scientific Evidence and Biological Mechanisms; Giuseppe Grosso, et al. Oxid Med Cell Longevity. 2014; 2014: 313570.
Fish consumption, long-chain omega-3 fatty acids and risk of cognitive decline or Alzheimer disease: a complex association. Fotuhi M, Mohassel P, Yaffe K. Nat Clin Pract Neurol. 2009 Mar;5(3):140-52.
Short-term supplementation of acute long-chain omega-3 polyunsaturated fatty acids may alter depression status and decrease symptomology among young adults with depression: A preliminary randomized and placebo controlled trial. Annie T.Ginty, Sarah M.Conklin; Psychiatry Research
Circulating omega-3 Fatty acids and neovascular age-related macular degeneration. Merle BM et al: Invest Ophthalmol Vis Sci. 2014 Mar 28;55(3):2010-9. doi: 10.1167/iovs.14-13916.
Dietary fish oil decreases C-reactive protein, interleukin-6, and triacylglycerol to HDL-cholesterol ratio in postmenopausal women on HRT. Ciubotaru I, Lee YS, Wander RC; J Nutr Biochem. 2003 Sep;14(9):513-21.
Omega-3 Fatty Acids and Depression: Scientific Evidence and Biological Mechanisms; Giuseppe Grosso et al. Oxid Med Cell Longevity. 2014; 2014: 313570.
Age- and dose-dependent effects of an eicosapentaenoic acid-rich oil on cardiovascular risk factors in healthy male subjects. Cazzola R1, Russo-Volpe S, Miles EA, Rees D, Banerjee T, Roynette CE, Wells SJ, Goua M, Wahle KW, Calder PC, Cestaro B. Atherosclerosis. 2007 Jul;193(1):159-67. Epub 2006 Aug 1.
Omega-3 fatty acid supplements improve the cardiovascular risk profile of subjects with metabolic syndrome, including markers of inflammation and auto-immunity. Ebrahimi M, Ghayour-Mobarhan M, Rezaiean S, Hoseini M, Parizade SM, Farhoudi F, Hosseininezhad SJ, Tavallaei S, Vejdani A, Azimi-Nezhad M, Shakeri MT, Rad MA, Mobarra N, Kazemi-Bajestani SM, Ferns GA. Acta Cardiol. 2009 Jun;64(3):321-7.
https://www.bda.uk.com/foodfacts/omega3.pdf. Volume 229, Issues 1–2, 30 September 2015,
Inflammation and cancer. Coussens LM, Werb Z. Nature. 2002 Dec 19-26;420(6917):860-7.
Inflammatory links between obesity and metabolic disease. Lumeng CN, Saltiel AR. J Clin Invest. 2011 Jun;121(6):2111-7. doi: 10.1172/JCI57132. Epub 2011 Jun 1.
Omega-3 supplementation lowers inflammation and anxiety in medical students: a randomized controlled trial. Kiecolt-Glaser JK, Belury MA, Andridge R, Malarkey WB, Glaser R; Brain Behav Immun. 2011 Nov;25(8):1725-34. doi: 10.1016/j.bbi.2011.07.229. Epub 2011 Jul 19.
Relationship between fatty acids and the endocrine and neuroendocrine system. Bhathena SJ. Nutr Neurosci. 2006 Feb-Apr;9(1-2):1-10.
The role of carotenoids in human health. Johnson EJ. PubMed 2002 Mar-Apr;5(2):56-65.
Lutein/Zeaxanthin and Omega-3 Fatty Acids for Age-Related Macular Degeneration. The Age-Related Eye Disease Study 2 (AREDS2) Controlled Randomized Clinical Trial. JAMA, published online May 5, 2013.
Retinoid chemoprevention in patients at high risk for skin cancer. DiGiovanna JJ. Med Pediatr Oncol. 2001;36:564-567.
Fruits and vegetables that are sources for lutein and zeaxanthin: the macular pigment in human eyes;Olaf Sommerburg, Jan E E Keunen, Alan C Bird, Frederik J G M van Kuijk; British Journal of Opthalmology
Dietary carotenoids and vitamins A, C, and E and risk of breast cancer. Zhang S, Hunger DJ, Forman MR, et al. J Natl Cancer Inst. 1999;91:547-556.
Beta-carotene supplementation for patients with low baseline levels and decreased risks of total and prostate carcinoma. Cook N, Stampfer MJ, Ma J, et al. Cancer. 1999;86:1783-1792.
Lycopene attenuates oxidative stress induced experimental cataract development: an in vitro and in vivo study.Gupta SK, Trivedi D, Srivastava S, Joshi S, Halder N, Verma SD; Nutrition. 2003 Sep;19(9):794-9.
Lycopene acts through inhibition of IκB kinase to suppress NF-κB signaling in human prostate and breast cancer cells. Assar EA, Vidalle MC, Chopra M, Hafizi S. Tumour Biol. 2016 Jul;37(7):9375-85. doi: 10.1007/s13277-016-4798-3. Epub 2016 Jan 16.
Dietary lycopene intake and risk of prostate cancer defined by ERG protein expression. Graff RE, Pettersson A, et al: Am J Clin Nutr. 2016 Mar;103(3):851-60. doi: 10.3945/ajcn.115.118703. Epub 2016 Jan 27.
Lycopene in the prevention of renal cell cancer in the TSC2 mutant Eker rat model. Sahin K, Cross B, et al: Arch Biochem Biophys. 2015 Apr 15;572:36-39. doi: 10.1016/j.abb.2015.01.006. Epub 2015 Jan 17.
Lycopene attenuates Aβ1-42 secretion and its toxicity in human cell and Caenorhabditis elegans models of Alzheimer disease. Chen W, Mao L et al, Neurosci Lett. 2015 Nov 3;608:28-33. doi: 10.1016/j.neulet.2015.10.009. Epub 2015 Oct 28
Lycopene Prevents Amyloid [Beta]-Induced Mitochondrial Oxidative Stress and Dysfunctions in Cultured Rat Cortical Neurons.Qu M, Jiang Z, Liao Y, Song Z, Nan X: Neurochem Res. 2016 Jun;41(6):1354-64. doi: 10.1007/s11064-016-1837-9. Epub 2016 Jan 27.
A randomized trial of beta carotene supplementation and cognitive function in men: the Physicians’ Health Study II.Grodstein F, Kang JH, Glynn RJ, Cook NR, Gaziano JM. Arch Intern Med. 2007 Nov 12;167(20):2184-90.
Effects of dietary antioxidant vitamins on lung functions according to gender and smoking status in Korea: a population-based cross-sectional study; Ji Young Hong et al; Respiratory Medicine
Effect of soy isoflavones on blood pressure: a meta-analysis of randomized controlled trials. Liu XX et al. Nutr Metab Cardiovasc Dis. 2012 Jun;22(6):463-70. doi: 10.1016/j.numecd.2010.09.006. Epub 2011 Feb 9.
Clinical studies show no effects of soy protein or isoflavones on reproductive hormones in men: results of a meta-analysis. Hamilton-Reeves JM, Vazquez G, Duval SJ, Phipps WR, Kurzer MS, Messina MJ. Fertil Steril. 2010 Aug;94(3):997-1007. doi: 10.1016/j.fertnstert.2009.04.038. Epub 2009 Jun 12
Soy and soy isoflavones in prostate cancer: a systematic review and meta-analysis of randomized controlled trials. van Die MD, Bone KM, Williams SG, Pirotta MV. BJU Int. 2014 May;113(5b):E119-30. doi: 10.1111/bju.12435.
Quantitative efficacy of soy isoflavones on menopausal hot flashes. Lujin Li, Yinghua Lv, Ling Xu, Qingshan Zheng; Br J Clin Pharmacol. 2015 Apr; 79(4): 593–604.
The Effect of Soy Isoflavones on the Menopause Rating Scale Scoring in Perimenopausal and Postmenopausal Women: A Pilot Study. Marya Ahsan and Ayaz Khurram Mallick; J Clin Diagn Res. 2017 Sep; 11(9): FC13–FC16.
Endothelial Dysfunction: Cardiovascular Risk Factors, Therapy, and Outcome. Hadi AR Hadi; Vasc Health Risk Manag. 2005 Sep; 1(3): 183–198.
Soy and Its Isoflavones: The Truth Behind the Science in Breast Cancer. Crystal C. Douglas et al; Anti-Cancer Agents in Medicinal Chemistry; Volume 13, Issue 8, 2013
Soy proteins and isoflavones affect bone mineral density in older women: a randomized controlled trial. Anne M Kenny et al; Am J Clin Nutr. 2009 Jul; 90(1): 234–242.
Potassium, magnesium, and fruit and vegetable intakes are associated with greater bone mineral density in elderly men and women. Tucker KL, Hannan MT, Chen H, et al. (1999) Am J Clin Nutr 69:727-736
Beneficial effects of green tea: A literature review Sabu M Chacko, Chin Med. 2010; 5: 13. Published online 2010 Apr 6. doi: 10.1186/1749-8546-5-13
Molecular understanding of Epigallocatechin gallate (EGCG) in cardiovascular and metabolic diseases. Eng QY, Thanikachalam PV, Ramamurthy S. J Ethnopharmacol. 2018 Jan 10;210:296-310. doi: 10.1016/j.jep.2017.08.035. Epub 2017 Aug 31
Efficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing 24-h energy expenditure and fat oxidation in humans. Abdul G Dulloo; The American Journal of Clinical Nutrition, Volume 70, Issue 6, 1 December 1999
Effect of green tea extract on obese women: A randomized, double-blind, placebo-controlled clinical trial. Chung-Hua et al; Clinical Nutrition Volume 27, Issue 3, June 2008, Pages 363-370
Green tea catechin, epigallocatechin-3-gallate (EGCG): mechanisms, perspectives and clinical applications. Singh BN, Shankar S, Srivastava RK. Biochem Pharmacol. 2011 Dec 15;82(12):1807-21. doi: 10.1016/j.bcp.2011.07.093. Epub 2011 Jul 30.
Effects of tea intake on blood pressure: a meta-analysis of randomised controlled trials; Gang Liu. British Journal of Nutrition; Volume 112, 14 October 2014 , pp. 1043-1054
Benefits Of Green Tea In Reducing An Important Risk Factor For Heart Disease; European Society of Cardiology
L-theanine, a natural constituent in tea, and its effect on mental state. Nobre AC, Rao A, Owen GN. Asia Pac J Clin Nutr. 2008;17 Suppl 1:167-8.
Effectiveness and safety of Glucosamine, chondroitin, the two in combination, or celecoxib in the treatment of osteoarthritis of the knee. Chao Zeng et al: Sci Rep. 2015; 5: 16827
Effects of glucosamine, chondroitin, or placebo in patients with osteoarthritis of hip or knee: network meta-analysis. Wandel S, Jüni P, Tendal B et al. BMJ 2010;341:c4675
Current Role of Glucosamine in the Treatment of Osteoarthritis J.-Y. Reginster; O. Bruyere; A. Neuprez. Rheumatology 2007; 46(5):731-735.
The association between vitamin K status and knee osteoarthritis features in older adults: The Health, Aging and Body Composition Study. M. Kyla Shea et al: Osteoarthritis Cartilage. 2015 Mar; 23(3): 370–378.
Boswellia Serrata, A Potential Anti-inflammatory Agent: An Overview. M. Z. Siddiqui; Indian J Pharm Sci. 2011 May-Jun; 73(3): 255–261.
Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee–a randomized double blind placebo controlled trial. Kimmatkar N, Thawani V, Hingorani L, Khiyani R. Phytomedicine. 2003 Jan;10(1):3-7.
Frankincense oil derived from Boswellia carteri induces tumor cell specific cytotoxicity. Frank MB, BMC Complement Altern Med. 2009 Mar 18;9:6. doi: 10.1186/1472-6882-9-6.
Curcumin: A Review of Its Effects on Human Health: Susan J. Hewlings and Douglas S. Kalman; Foods. 2017 Oct; 6(10): 92.
https://www.sciencedirect.com/topics/medicine-and-dentistry/5-lipoxygenase-inhibitors
Chondroitin sulfate seems as effective for knee osteoarthritis as widely used celecoxib. BMJ 2017; 357 doi: https://doi.org/10.1136/bmj.j2515 (Published 24 May 2017)
Low Dose Betaine Supplementation Leads to Immediate and Long Term Lowering of Plasma Homocysteine in Healthy Men and Women. Margreet R. Olthof, Trinette van Vliet, Esther Boelsma, Petra Verhoef. The Journal of Nutrition, Volume 133, Issue 12, 1 December 2003
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