Soy anti-cancer, good for menopause, heart and bone health

Soy anti-cancer, good for menopause, heart and bone health NutriShield Multi Vitamins and Minerals


DEFINITIVE GUIDE TO SOY AT A GLANCE

♦ SOY and its isoflavones are linked to lower breast cancer risk
♦ SOY and its isoflavones can reduce negative symptoms experienced during the menopause and help alleviate PMS symptoms for younger women
♦ SOY and its isoflavones can help lower blood pressure and improve heart health
♦ SOY and its isoflavones can contribute to stronger bones
♦ SOY and its isoflavones do NOT adversely affect male sex hormones – and may reduce prostate cancer risk


Cancer risk reduction for men and women

About 1 in 11 British women will develop breast cancer at some time in their lives. In Japan, the figure is as low as 1 in 65.

Epidemiologists – scientists who study outcome patterns in populations – believe that soy may play a crucial protective role against cancer.

The Japanese diet contains considerably more soy products than the typical Western one does, and that’s thought to protect against breast cancer – and indeed other cancers.

Soy beans are extremely rich in isoflavones, and these seem to be among the most potent anti-carcinogens of all.

Isoflavones block oestrogen, a hormone linked to an increased risk of breast and other hormone-dependent cancers. They act rather like Tamoxifen, a drug widely used to treat and prevent breast cancer.

Men who think that soy is just for women should think again; considering the high rate of prostate cancer in the West, it seems that men have just as much to gain from adding soy to their diet. And soy isoflavones do NOT adversely affect male hormones like testosterone – see below.

Soy isoflavones can help in the menopause

Soy anti-cancer, good for menopause, heart and bone health NutriShield Multi Vitamins and MineralsIsoflavones can also mimic the effect of oestrogen in the body. Research shows that they can significantly alleviate the negative symptoms that many women go through during the menopause.

Two of the most distressing symptoms during the menopause are hot flushes [in the US, called “hot flashes”] during the day and night sweats during bedtime. They are caused because, as oestrogen levels fall, what’s called ‘vasomotor function’ deteriorates.

Blood vessels on the surface of the skin normally dilate when we are hot – allowing hot blood to move to the surface and the heat to escape. But this ‘vasomotor’ sequence is affected by the hormonal changes at menopause, causing the surface blood vessels to dilate randomly and the skin to become hot and sweaty.

It’s known that Japanese women on average suffer fewer menopausal symptoms than Western women – and they consume far more soy.  Indeed, the average Japanese intake of soy isoflavones is at least 15mg a day, compared with 1mg average in the West.

After earlier conflicting evidence that soy could ease menopausal symptoms, a 2012 meta-analysis (a literature survey of existing clinical trials) confirmed that:

Consumption of 30mg/day of soy isoflavones … reduces hot flashes by up to 50%.”

Isoflavones are phytoestrogens

The key isoflavone nutrients in soy isoflavones are genistein and daidzein. These are found in soy beans, and to a lesser extent in chick peas and lentils, and they appear to be the most potent of the phytoestrogens.

It should be noted that the oestrogen potency of phytoestrogens is estimated to be less than 1% of oestradiol, the natural oestrogen, and this probably explains why earlier studies did not clearly show isoflavones to be effective in ameliorating the menopausal symptoms. After all, hormone levels vary significantly from woman to woman.

However, a recent (2017) study in the Journal of Clinical and Diagnostic Research once again confirmed that:

“Soy isoflavone improves the MRS score (a measurement of menopause symptoms) among both the perimenopausal (women transitioning into menopause) and postmenopausal women.”

A fair conclusion is that women who do not want to take hormone (replacement) therapy (HT or HRT) with oestrogen, and certainly women who have had breast cancer, should consider a supplement that includes soy isoflavones for relief of menopausal symptoms.

When NICE (the National Institute for Health and Care Excellence), published guidelines in 2015 for the menopause, they confirmed there is evidence that isoflavones may relieve vasomotor symptoms.

Soy isoflavones can help with PMS

Soy anti-cancer, good for menopause, heart and bone health NutriShield Multi Vitamins and MineralsSo far, we have concentrated on the benefits of soy isoflavones for older women. But new research has highlighted the fact that soy isoflavones – in soy or a supplement – can reduce PMS symptoms.

The National Association for Premenstrual Syndrome now states:

“Our data on this is limited; however, women in Asia, who have high levels of phytoestrogens in their diet, do have fewer PMS symptoms.”

They also recommend a diet that’s high in Omega 3, B complex, vitamin D, magnesium and calcium to help relieve PMS symptoms.

Soy isoflavones for heart health

Soy anti-cancer, good for menopause, heart and bone health NutriShield Multi Vitamins and MineralsLack of oestrogen after the menopause means that a woman’s risk of heart disease becomes comparable to a man’s. So it is logical that the plant oestrogens in soy isoflavones could be part of a heart health regime – for both women and men.

An article in Current Nutrition & Food Science confirmed that soy isoflavones were helpful in reducing blood pressure (see below), but that their effects were even stronger in preventing what doctors call ‘endothelial dysfunction’.

Preventing endothelial dysfunction

The endothelium is the thin lining on the inside of your blood vessels and arteries. It’s a vital part of the regular restriction and dilation that occurs over 60 times a minute as the heart beats. And all taking place within the almost 90,000 miles (!) of blood vessels that make up the arteries, veins and capillaries in the body.

The endothelium needs to be flexible and smooth to achieve healthy blood pressure and flow. In endothelial dysfunction, oxidation (free radical damage) causes lesions in this lining; LDL cholesterol sticks to these lesions and causes atherosclerosis – a build-up of fats that can then semi-calcify, all resulting in a narrowing and hardening of the arteries.

The result is atherosclerosis, hypertension and heart disease.

Isoflavones not only act as anti-oxidants to counteract excess free radical damage – they also reduce inflammation and help restore smoothness in the endothelium. A study in the European Heart Journal showed that as little as 12 weeks of isoflavone supplementation ‘reversed endothelial dysfunction’. The report concluded that:

“These findings may have important implications for the use of isoflavone for secondary prevention in patients with cardiovascular disease, on top of conventional interventions.”

Another meta-analysis of over 20 studies in Cardio-Vascular Discoveries Journal confirmed that isoflavones improved heart health, concluding that:

“Soy isoflavones had an effect of lowering blood pressure in hypertensive subjects.”

Soy isoflavones for bone health

Soy anti-cancer, good for menopause, heart and bone health NutriShield Multi Vitamins and MineralsLack of oestrogen also predisposes a woman to osteoporosis (bone loss). Indeed, osteoporosis means ‘porous bones’. So it’s logical that a isoflavone supplement might help preserve bone density in older women. Asian women, who consume far more soy than Western women, rarely suffer from osteoporosis after the menopause.

However, a well-conducted study reported in the American Journal of Clinical Nutrition found no difference in bone density after isoflavone supplementation. But it did find that increased protein intake improves bone density.

In a way that’s not surprising, because bone density is a function of much more than oestrogen. It needs adequate calcium, vitamins A and D that support the absorption of calcium, and minerals like magnesium and zinc, plus vitamin K, which are all needed to mineralise bone.

Soy isoflavones and breast cancer

Soy anti-cancer, good for menopause, heart and bone health NutriShield Multi Vitamins and MineralsPopulation studies show that eating a high-soy diet is linked to a slightly reduced risk of developing breast cancer.

As we have seen, Asian women with a traditional diet high in soy, appear to be less likely to develop breast cancer. This benefit continues even when Asian women move to western cultures, where soy is less likely to be a regular part of the diet. This suggests that exposure to soy early in life provides the most protection against breast cancer.

When small amounts of soy are fed to animals, their rate of breast cancer falls by nearly 50%, as does the incidence of prostate cancer.

A survey in the specialist journal Anti-Cancer Agents in Medicinal Chemistry confirmed these population observations concluding that:

“The majority of breast cancer cases are hormone-receptor-positive; therefore, soy isoflavones should be considered a potential anti-cancer therapeutic agent.”

Genistein appears to be the key isoflavone. Whilst it has little effect on normal cells, it appears to be a powerful inhibitor of nearly every cancer cell type examined so far.

But genistein doesn’t just inhibit cancer cells. In vitro it can cause cancer cells to revert to normal cells – which is an absolutely crucial anti-cancer property, called ‘re-differentiation’.

Genistein seems to have yet another another amazing property. It inhibits the growth of new blood vessels, and may therefore be able to starve cancers even after they have begun to grow.

Other nutrients can work with soy to increase cancer protection. If you follow a modified Mediterranean Diet with a supplement that includes vitamin D, vitamin E, selenium, carotenoids like lutein and lycopene, Omega 3, betaine, green tea and grapeseed extract, you will have the basis of a strong, evidence-based anti-cancer regime.

Soy isoflavones and men’s health – NO adverse effects

Soy anti-cancer, good for menopause, heart and bone health NutriShield Multi Vitamins and MineralsIf soy isoflavones act as oestrogen mimics, are they safe for men – and do they affect testosterone levels or sex drive?

A survey of 47 studies on that subject is quite clear – they don’t adversely affect men. The summary in Fertility Journal concluded:

“The results of this meta-analysis suggest that neither soy foods nor isoflavone supplements alter measures of bioavailable T (testosterone) concentrations in men”.

But why? First of all, men produce the hormone oestrogen too – albeit at lower levels than women.

Secondly, we have seen that the hormone effect of soy isoflavone phytoestrogens is almost 100 times less than that of oestradiol, the natural form of oestrogen.

Thirdly, Asian men who consume many times more isoflavones from soy than Western men, have no lower levels of fertility and sex drive.

In fact, the International Society of Sexual Medicine answers the question: “Does consuming soy affect a man’s testosterone level?” with the simple answer: ‘NO’.

There is some evidence, however, that taking isoflavones does increase a woman’s desire levels, as lower oestrogen is linked to vaginal dryness and lower libido.  A diet rich in B complex vitamins, vitamin E, with isoflavones (plus exercise and de-stressing) does seem to deliver a libido boost – especially during and after the menopause.

Soy isoflavones and prostate cancer

Soy anti-cancer, good for menopause, heart and bone health NutriShield Multi Vitamins and MineralsThe US National Library of Medicine published a summary of all the research on the impact of soy isoflavones on prostate cancer.

They found:

“a significant reduction in PCa (Prostate Cancer) diagnosis after administration of soy/soy isoflavones. There may be support for epidemiological findings of a potential role for soy/soy isoflavones in PCa risk reduction.”

Once again, men looking to achieve a significant reduction in the risk of prostate cancer would not rely on one ingredient like soy isoflavones.

But as we just advised for women, a Modified Mediterranean Diet with a supplement that also includes vitamin D, vitamin E, carotenoids like lutein and lycopene, Omega 3, betaine, green tea and grapeseed extract, provides the basis of a strong, evidence-based anti-cancer regime.

Soy supplements

Soy isoflavones on their own are not the only or ideal health protective nutrients. NutriShield Premium is a daily comprehensive supplement containing 43 nutrients including 40mg of soy isoflavones with 28.8mg of genistein, 9.6mg of daidzein and 1.6mg of glycitin, designed by Dr Paul Clayton, former Chair of the Forum on Food and Health at the Royal Society of Medicine.

Soy anti-cancer, good for menopause, heart and bone health NutriShield Multi Vitamins and Minerals

 


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Soy anti-cancer, good for menopause, heart and bone health NutriShield Multi Vitamins and Minerals And register now for a free regular e-newsletter on the latest in nutrition and health research.


Dr Paul Clayton designed NutriShield as a comprehensive healthSoy anti-cancer, good for menopause, heart and bone health NutriShield Multi Vitamins and Minerals supplement with OPTIMUM levels of 43 essential nutrients including soy isoflavones, polyphenols and flavonoids from fruits, vegetables and other plants, Omega 3, betaine and greent tea. See more detail elsewhere on this site or click on the button.


Soy anti-cancer, good for menopause, heart and bone health NutriShield Multi Vitamins and MineralsDr Paul Clayton’s best-selling book Health Defence is available from bookstores or from Uni-Vite Healthcare here.

A free summary report and the opportunity to read the book online is available here.


See online here for delicious recipes from the Health Defence Cookbook  incorporating healthy foods featuring in a Mediterranean Diet. Soy anti-cancer, good for menopause, heart and bone health NutriShield Multi Vitamins and Minerals


REFERENCES

Effect of soy isoflavones on blood pressure: a meta-analysis of randomized controlled trials. Liu XX, et al; Nutr Metab Cardiovasc Dis. 2012 Jun;22(6):463-70. doi: 10.1016/j.numecd.2010.09.006. Epub 2011 Feb 9.

Clinical studies show no effects of soy protein or isoflavones on reproductive hormones in men: results of a meta-analysis. Hamilton-Reeves JM, Vazquez G, Duval SJ, Phipps WR, Kurzer MS, Messina MJ. Fertil Steril.  2010 Aug;94(3):997-1007. doi: 10.1016/j.fertnstert.2009.04.038. Epub 2009 Jun 12

Soy and soy isoflavones in prostate cancer: a systematic review and meta-analysis of randomized controlled trials. van Die MD, Bone KM, Williams SG, Pirotta MV. BJU Int. 2014 May;113(5b):E119-30. doi: 10.1111/bju.12435.

Quantitative efficacy of soy isoflavones on menopausal hot flashes. Lujin Li, Yinghua Lv, Ling Xu, and Qingshan Zheng; Br J Clin Pharmacol. 2015 Apr; 79(4): 593–604.

The Effect of Soy Isoflavones on the Menopause Rating Scale Scoring in Perimenopausal and Postmenopausal Women: A Pilot Study. Marya Ahsan and Ayaz Khurram Mallick. J Clin Diagn Res. 2017 Sep; 11(9): FC13–FC16.

Endothelial Dysfunction: Cardiovascular Risk Factors, Therapy, and Outcome: Hadi AR Hadi, Vasc Health Risk Manag. 2005 Sep; 1(3): 183–198.

Soy and Its Isoflavones: The Truth Behind the Science in Breast Cancer:  Crystal C. Douglas et al;  Anti-Cancer Agents in Medicinal Chemistry; Volume 13 , Issue 8 , 2013

Soy proteins and isoflavones affect bone mineral density in older women: a randomized controlled trial. Anne M Kenny, et al; Am J Clin Nutr. 2009 Jul; 90(1): 234–242.

Potassium, magnesium, and fruit and vegetable intakes are associated with greater bone mineral density in elderly men and women.  Tucker KL, Hannan MT, Chen H, et al. (1999)  Am J Clin Nutr 69:727-736

 

 

Glucosamine and joint health

Definitive guide to benefits of glucosamine

Glucosamine and joint health NutriShield Multi Vitamins and Minerals

 


DEFINITIVE GUIDE TO GLUCOSAMINE AT A GLANCE

♦ GLUCOSAMINE has been proven to help improve joint health, but it needs the addition of vitamins C, D3 and K2 to be truly effective
♦ GLUCOSAMINE is also helped by Omega 3 in cases of osteo-arthritis
♦ Pain relief from inflammation can be more safely addressed with curcumin and Boswellia in conjunction with GLUCOSAMINE, rather than drugs with side-effects which can become addictive
♦ There is little evidence for adding MSM or collagen to GLUCOSAMINE, but chondroitin may improve outcomes in cases of joint deterioration


The treatment of osteoarthritis and joint pain through glucosamine, or glucosamine and chondroitin combined, has been controversial.

Controversial, because although millions of people use glucosamine, many organisations – like Arthritis Research UK and the American Academy of Orthopaedic Surgeons – have been unimpressed with the effectiveness of either glucosamine or chondroitin. A BBC report concluded that exercise works just as well as glucosamine.

Meta analysis showed glucosamine effective

However, in 2015 a meta-analysis of 54 separate clinical trials on glucosamine was published in Science Reports. It covered a total of 16,427 patients and examined the effectiveness of glucosamine alone, of glucosamine plus chondroitin, and celecoxib, the leading drug that is designed to reduce inflammation and pain.

The conclusion? They were all more effective than a placebo for pain relief and joint function improvement.

All treatment options ‘showed clinically significant improvement from baseline pain’.

In terms of what the report called the ‘structure-modifying effect’, both glucosamine alone and chondroitin alone achieved a statistically significant reduction in joint space narrowing – implying that cartilage had been regrown.

So glucosamine works?

Yes – but that’s not the whole story.

You need more than glucosamine to build cartilage

Glucosamine and joint health NutriShield Multi Vitamins and MineralsGlucosamine is one of the building blocks of cartilage, ligaments and tendons. It is produced naturally by the body by combining sugars and proteins. Cartilage is the natural cushioning between joints and the lubrication between those joints is called synovial fluid.

Problems and pain arise when, over time, cartilage begins to breakdown – leading to osteo-arthritis. Osteoarthritis (OA), is the most common form of arthritis, and is a significant public health problem – affecting an average of 25% of men and somewhat more women over the age of 60 years.

The theory is that by supplying more of the glucosamine building block, it should give your body what it needs to make repairs and increase the level of cartilage. In turn, that should improve mobility and reduce pain.

But that misses the point that cartilage repair needs more than glucosamine. In particular, production of cartilage needs vitamins C and D.

In addition, researchers have noticed that people low in vitamin K2 have significantly worse cartilage loss and arthritis symptoms – because vitamin K plays an important role in both cartilage and bone mineralisation.

And vitamins C, D and K2 are missing in most glucosamine joint supplements.

The addition of Omega 3

Recent research conducted at the University of Bristol and funded by Arthritis Research UK – has also found that Omega-3-rich diets may reduce arthritis symptoms “by 50 per cent compared to a standard diet”. They noted that:

“classic early signs of the condition (ie arthritis) such as the degradation of collagen in cartilage and the loss of molecules that give it shock-absorbing properties, were both reduced with omega-3.”

The Bristol study was conducted with guinea pigs who are prone to arthritis, but the biological processes are the same in humans.

The flawed “single-nutrient” approach with glucosamine alone

We can now see why studies on glucosamine alone have historically shown such varied results. Very rarely does one nutrient have a major impact on health. The body is complex and only a range of nutrients working synergistically is likely to have a significant result.

Combine glucosamine with vitamins C, D2 and K2 plus Omega 3 and you have a formula for an effective way to start building cartilage.

But even that’s not enough!

You need safe pain relief too

Osteoarthritis is an inflammatory disease – as is any disease ending in ‘-itis’. And it’s the inflammation that ultimately causes the pain.

So, to have a comprehensive approach to arthritis, you need not just the nutrients that help rebuild cartilage – but to reduce pain whilst that rebuilding process is going on.

The problem with drugs

The pharmaceutical drug to tackle inflammatory pain is celecoxib. It is a Cox-2 inhibitor – hence the ‘coxib’ part of the name – meaning coxinhibitor.

Classified as an NSAID – a Non-Steroidal Anti-Inflammatory Drug – Celecoxib works by blocking a pain pathway. [It blocks an enzyme called 5-lipox that makes prostaglandins and reducing prostaglandins reduces pain and swellings.]

However, there have been fears that NSAIDs could increase heart attack risk. Other side effects can include stomach upsets and headaches.

Natural and safe COX-2 pain inhibitors curcumin and boswellia

Fortunately, there are natural and safe Cox-2 pain inhibitors, the most effective being curcumin and Boswellia.

Curcumin is a constituent of the turmeric root – a very powerful natural anti-inflammatory and anti-oxidant. A 2017 review of over 100 studies on curcumin in the scientific magazine Foods concluded curcumin was indeed a powerful anti-inflammatory and that:

“Turmeric extracts and curcumin can be recommended for alleviating the symptoms of arthritis, especially osteoarthritis.”

Curcumin, however, has a disadvantage in that it is not very bio-available – ie. not easily absorbed in the gut. But it can be ‘standardised’ at a high purity (over 90%) level and, if it is accompanied by natural ingredients such as piperine and lecithin, its bioavailability is increased many times.

Piperine is derived from black pepper and lecithin is an essential fat that helps regulate kidney function.

Boswellia serrata has been used for centuries for arthritis and other inflammatory conditions, as it inhibits a pro-inflammatory enzyme called 5-lipoxygenase. Arthritis sufferers have found it can bring substantial relief from swelling and stiffness in as little as 7 days.

A randomised double-blind trial (the gold standard in medical research) published in Phyto-Medicine concluded that:

“Boswellia is recommended in patients with osteoarthritis of the knee, with possible therapeutic use in other arthritis.”

Boswellia is derived from the a relative of the frankincense plant (given by the Three Wise Men!) and recently researchers have also been focusing on its anti-cancer potential.

Specifically, Boswellia includes terpenes which are strong-smelling compounds that create the perfume of incense. But in this case, the terpenes in Boswellia inhibit certain pro-inflammatory proteins (called cytokines) that can damage DNA, promote tumour growth and destroy healthy cells.

Excess pro-inflammatory cytokines are indeed the driver of inflammation generally and arthritic damage specifically. And that and an explanation of the role of prostaglandins is explored in this article by Dr Paul Clayton.

Collagen, MSM and chondroitin

The prestigious Mayo Clinic has studied joint supplements and their conclusions are that:

“Research has not found any proof that these extra ingredients (ie. chondroitin, MSM or shark cartilage) make glucosamine more effective than glucosamine alone.”

That makes sense.

MSM – No positive evidence

Methylsulfonylmethane is a naturally occurring form of sulphur that supports muscles and tendons. It is not, however, part of the process that helps rebuild cartilage.

Collagen – Very limited positive evidence

This is a protein and an essential structural component in skin, cartilage and ligaments and tendons. Indeed, it’s the main protein in the body overall.

There is some evidence that a collagen supplement can help alleviate joint pain, but it may be better – considering how abundant collagen is – to support the body’s own creation of collagen. That requires vitamin C, vitamin E, copper and zinc – all co-factors for collagen.

Some people, like Salma Hayek and Elle MacPherson, swear by bone broth which is full of collagen because they believe it makes their skin look younger.

Chondroitin – Positive evidence, as similar to glucosamine

Chondroitin, like glucosamine, is found naturally in your body. It is a vital part of cartilage, giving it elasticity by helping it retain water.

Laboratory studies have found that chondroitin can reduce the activity of enzymes and substances that break down collagen in joints. And other studies have demonstrated that it has several anti-inflammatory properties.

Arthritis UK reports that evidence of use of chondroitin as a joint supplement “… is inconsistent, but many show that it has significant clinical benefits in reducing pain and painkiller use”.

A 2017 article in the British Medical Journal reported research published online in the Annals of the Rheumatic Diseases that:

“Pharmaceutical-grade chondroitin sulfate is as effective as the widely prescribed non-steroidal anti-inflammatory drug (NSAID) celecoxib for treating painful knee osteoarthritis.”

Chondroitin and glucosamine are very similar in the way they affect cartilage – which is why the major study in Science Reports already quoted concluded that you can take either glucosamine or chondroitin and get relief. Combining them may offer a small advantage.

Glucosamine does NOT cause liver damage

There have been a (very) few concerns that glucosamine might cause liver damage. But data from the numerous trials in human volunteers for both glucosamine (and chondroitin), as well as the more limited animal toxicology data, do not indicate any adverse effects of glucosamine on the liver. Glucosamine occurs naturally within the human body and no plausible mechanism by which it might cause hepatotoxicity is apparent.

Summary

Glucosamine on its own has a positive effect on joint mobility. But that is improved by the addition of vitamins D3 and K2. Adding Omega 3 to your diet or supplement regime will further improve outcomes.

In NutriShield Premium, a daily comprehensive supplement containing 43 nutrients, designed by Dr Paul Clayton, former Chair of the Forum on Food and Health at the Royal Society of Medicine, the daily dose includes 415mg Glucosamine, 250mg of 95% Curcuminoids (supplemented with piperine), 650mg of Omega 3 fish oil, 500mg of Vitamin C, 20mcg of Vitamin D3 and 75mcg of Vitamin K, of which 25mcg is K2.

For a full joint restorative health programme, particularly in pre-existing conditions, add more curcumin and Boswellia serrata to damp down inflammation.

In a joint supplement, make sure that the curcumin is at least 95% pure, and its bio-availability is enhanced with piperine and lecithin. That combination is in JointShield – see https://www.uni-vite.com/jointshield/whats-in-jointshield/

 


If you enjoyed this article, please share it with family and friends. You can follow us on Facebook or Twitter for daily headline health tweets.


Glucosamine and joint health NutriShield Multi Vitamins and Minerals And register now for a free regular e-newsletter on the latest in nutrition and health research.


Dr Paul Clayton designed NutriShield as a comprehensive healthGlucosamine and joint health NutriShield Multi Vitamins and Minerals supplement with OPTIMUM levels of 43 essential nutrients including polyphenols and flavonoids from fruits, vegetables and other plants, Omega 3, glucosamine and soy isoflavones. See more detail elsewhere on this site or click on the button.


Glucosamine and joint health NutriShield Multi Vitamins and MineralsDr Paul Clayton’s best-selling book Health Defence is available from bookstores or from Uni-Vite Healthcare here.

A free summary report and the opportunity to read the book online is available here.


See online here for delicious recipes from the Health Defence Cookbook  incorporating healthy foods featuring in a Mediterranean Diet. Glucosamine and joint health NutriShield Multi Vitamins and Minerals


REFERENCES

Effectiveness and safety of Glucosamine, chondroitin, the two in combination, or celecoxib in the treatment of osteoarthritis of the knee: Chao Zeng, et al: Sci Rep. 2015; 5: 16827.

Effects of glucosamine, chondroitin, or placebo in patients with osteoarthritis of hip or knee: network meta-analysis. Wandel S, Jüni P, Tendal B et al  BMJ 2010;341:c4675

Current Role of Glucosamine in the Treatment of Osteoarthritis J.-Y. Reginster; O. Bruyere; A. Neuprez. Rheumatology 2007; 46(5): 731-735.

The association between vitamin K status and knee osteoarthritis features in older adults: The Health, Aging and Body Composition Study; M. Kyla Shea et al: Osteoarthritis Cartilage. 2015 Mar; 23(3): 370–378.

Boswellia Serrata, A Potential Anti-inflammatory Agent: An Overview M. Z. Siddiqui. Indian J Pharm Sci. 2011 May-Jun; 73(3): 255–261.

Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee–a randomized double blind placebo controlled trial. Kimmatkar N, Thawani V, Hingorani L, Khiyani R. Phytomedicine. 2003 Jan;10(1):3-7.

Frankincense oil derived from Boswellia carteri induces tumor cell specific cytotoxicity. Frank MB, BMC Complement Altern Med. 2009 Mar 18;9:6. doi: 10.1186/1472-6882-9-6.

Curcumin: A Review of Its Effects on Human Health: Susan J. Hewlings and Douglas S. Kalman. Foods. 2017 Oct; 6(10): 92.

https://www.sciencedirect.com/topics/medicine-and-dentistry/5-lipoxygenase-inhibitors

Chondroitin sulfate seems as effective for knee osteoarthritis as widely used celecoxib BMJ 2017; 357 doi: https://doi.org/10.1136/bmj.j2515 (Published 24 May 2017)