How you can avoid Alzheimer’s

How you can avoid Alzheimer's NutriShield Multi Vitamins and Minerals

Cut your risk by 53% – or more

You can reduce your risk of Alzheimer’s by 53%, according to new research from Harvard University. And by adding just three more common nutrients to their dietary recommendations – you can cut the risk even further.

You’ve probably read that ageing is a risk factor for Alzheimer’s – but that’s not strictly accurate.

What is true, is that you normally accumulate damage to DNA, cells and organs as you age. It is this damage that results in Alzheimer’s – not the passing of the years.

So, the good news is that if you reduce, slow or prevent cell and tissue damage, major new research shows you can more than halve the risk of dementia.

The even better news is that, if you take the preventative action outlined below, you also cut your risk of heart disease and stroke – probably by as much as 80%.

This article was written by Colin Rose, a Senior Associate Member of the Royal Society of Medicine, who has been writing on science for 40 years.

Alzheimer’s facts and figures

A leading cause of death

Dementia is now the Number 1 cause of death in women and the Number 2 in men – according to the UK’s Office of National Statistics in 2017.

That’s because the brain ultimately controls everything – the heart, gastro-intestinal organs, metabolism, etc.  Dementia, therefore, becomes a terminal illness, leading to overall frailty, susceptibility to infections, eating problems, pneumonia and breathing difficulties. And is highly distressing to the individual and family.

70% of people with dementia have Alzheimer’s

About 70% of people with dementia have Alzheimer’s Disease, which involves a gradual decline in cognitive function. Vascular Dementia is caused by restricted blood flow, and therefore oxygen and nutrients, to the brain. It is often linked to high blood pressure, high cholesterol or follows a stroke or heart disease.

Most Alzheimer’s sufferers are over 65

Most people with Alzheimer’s Disease are 65 and older. After the age of 65, when the risk is about 2%-3%, the risk of Alzheimer’s DOUBLES every five years.

After age 85, the risk reaches almost 30% of all adults.

But if you are reading this, and are in your 50s or early 60s, you should note that Alzheimer’s is a stealthy threat. It begins at least 10 years before the symptoms become apparent in everyday behaviour.

So the time to take action is well before 65.

The genetic links are weak, except for those of Afro-Caribbean heritage

The risk of Alzheimer’s is doubled in people of Afro-Caribbean heritage – a genetic link.

Other genetic links are weak, so that someone of other heritage with a parent or grandparent who developed Alzheimer’s is at only slightly higher risk. But, according to the Alzheimer’s Association, “it is estimated that less than 1 percent of Alzheimer’s cases are caused by deterministic genes genes that cause a disease, rather than increase the risk of developing a disease)”.

Strong links with heart disease and stroke

There is a strong link between heart disease, stroke, ED (Erectile Dysfunction) and Alzheimer’s Disease. Because a healthy brain and a healthy heart both need unrestricted blood flow through arteries and blood vessels.

High blood pressure increases risk

For this reason, hypertension or high blood pressure increases the risk of Alzheimer’s

Brain ‘plaques’ and ‘tangles’

Alzheimer’s brains are characterised by ‘plaques’ and ‘tangles’. Plaques consist of dead brain cells and a protein called beta amyloid which is toxic. Tangles are made up of another protein called tau, which becomes abnormal and clumps together leading to neuron cell death and inhibited neural communication.

Noticeable change can take 10 years to show

These changes in the brain may take up to 10 years to become noticeable in behaviour.

Average survival from onset of symptoms is 8.4 years

The average survival time from the onset of symptoms is 8.4 years.

Diabetes increases risk

Diabetes increases the risk – but the development of diabetes can be slowed or prevented with the exact same programme as we discuss below.

Stress, obesity, smoking and alcohol increase risk

Chronic – long-term – stress increases the risk, as do obesity, smoking and high alcohol consumption.

Gum disease may be linked

There also may be a link between a bacterium that causes the gum disease gingivitis and Alzheimer’s.

No drugs yet that prevent or slow Alzheimer’s

There are no drugs yet that prevent or slow Alzheimer’s.

MIND Diet lowers Alzheimer’s risk by 53%

The MIND Diet was developed by Rush University and the Harvard School of Public Health in 2015. It stands for the Mediterranean/Dash Intervention for Neurodegenerative Delay – and combines the best of what were previously the world’s two most studied diets.  

These were the well-known Mediterranean Diet and the DASH Diet – the latter stands for Dietary Approaches to Stop Hypertension, developed at Harvard University.

The MIND Diet emphasises ‘brain foods’ that improve focus and memory – foods like berries (blueberries, raspberries, strawberries etc), lots of vegetables, green tea, Omega 3 rich oily fish (salmon, sardines, mackerel etc), whole grains, nuts and olive oil.

How you can avoid Alzheimer's NutriShield Multi Vitamins and Minerals

Why these foods? Because oily fish (and some nuts and seeds like walnuts and flaxseeds) provide Omega 3 which is important for brain health and normal neuron connections. Berry fruits and leafy greens are high in flavonoids and polyphenols which are brain protective.

A study published in the Journal of the Alzheimer’s Association found that adults following a MIND diet had a 53% lower risk of developing dementia than those eating a typical Western diet.

They went further – those eating the most MIND diet servings (in the top third of nutritional intake) were assessed as 7.5 years younger in biological age. Not just healthier brains, but younger brains!

But what is it in the MIND Diet that produces these results? Flavonoids and polyphenols

Flavonoids and polyphenols are a class of nutrients found in fruits and vegetables that are arguably as important for health as vitamins and minerals.

Flavonoids include the colourants in the skins of plants – powerful nutrients like the carotenoids, beta carotene, lycopene and lutein. Carotenoids help prevent the formation of the beta amyloid plaques and tangles that degrade neuron brain cells and characterise an Alzheimer’s brain. [They are also important anti-cancer nutrients.]

How you can avoid Alzheimer's NutriShield Multi Vitamins and Minerals

But flavonoids have another property. They have both an antioxidant and anti-inflammatory effect.

The brain is a fatty organ – and researchers have shown that oxidation or free radical damage to fats sheathing neurons in the brain is a contributory cause of dementia. Anti-oxidants counteract this oxidation and help prevent and slow that damage.

Inflammation in the brain is another contributory cause. So anti-inflammatory nutrients like flavonoids can help prevent inflammation damage.

The effect is not just to keep the brain healthy – the high antioxidant levels in the MIND diet help reduce free radical damage to DNA, tissues and cells throughout the body, which otherwise can lead to cancer.

Furthermore, the MIND diet is also a natural immune system booster. It’s high in vitamins and minerals like vitamin A, C and D, zinc, in flavonoids, carotenoids and in Omega 3 – all of which strongly support the immune system.

Finally, the MIND diet improves blood sugar levels and therefore helps protect against diabetes, which in turn lowers the risk of dementia.

Omega 3 is vital for brain health

Sometime between 195,000 and 125,000 years ago, humans nearly went extinct. An ice age set in and much of the earth was ice covered and uninhabitable. The population of our hominid ancestors may have crashed to as little as a few thousand – and most anthropologists agree that everyone alive today is descended from this small group.

The archaeological evidence is that this group almost certainly survived by extending their hunting and gathering to the coastal areas of Africa.

How you can avoid Alzheimer's NutriShield Multi Vitamins and Minerals

There they were able to harvest shellfish and cold-water fish which are rich in Omega 3 fatty acids. These fats, it is believed, helped drive the evolution of our highly complex brains – which are over 60% poly-unsaturated fat in composition.

Within Omega 3 is a compound called DHA. DHA is possibly the single most important nutrient for brain health. It facilitates the communication between brain cells and is critical to the growth and survival of healthy brain cells. It also helps reduce inflammation in the brain and in other body tissues.

In study after study, diets rich in Omega 3 are found to be protective of brain health. These include the Mediterranean diet, the Japanese Okinawan diet and certain Scandinavian diets.

Keep body and brain active to reduce risk too

The hippocampus is a part of the brain that is critical to memory. Normally it shrinks by 1 to 2 percent a year as you get older, leading to potential cognitive impairment, a prelude to dementia. But research shows that that just 40 minutes of brisk walking, three times per week, leads to significant brain growth.

In one study, adults who participated in aerobic exercise – the level where you breathe harder – saw an over 2% INcrease in the size of their hippocampus over one year, in contrast to a 1.4% decline in control subjects.

That’s because exercise raises levels of a brain chemical called BDNF that encourages the growth of new brain cells.

A University of California study shows that people who are regularly physically active have far fewer of the plaques and tangles that are characteristic of Alzheimer’s.

How you can avoid Alzheimer's NutriShield Multi Vitamins and Minerals

Finally, avoid sitting too long without a break. Taking a short break every hour and stretching for even a minute or two can make a significant difference to long-term brain and general health.

To physical activity add some mental effort, whether crosswords, sudoku, or learning something new like a musical instrument or language. Use it or lose it!

If your activities are done with others so much the better, because research shows loneliness can impair cognitive health.

Brush your teeth

Recent research, reported in 2019 in Science Advances and posted on the UK National Health Service site, has linked gum disease to Alzheimer’s.

How you can avoid Alzheimer's NutriShield Multi Vitamins and Minerals

The researchers have noted that bacteria called P. gingivalis, which cause gingivitis, are significantly more common in people with Alzheimer’s than in people without – almost doubly more common. And the harmful proteins produced by P. gingivalis are present in higher concentrations in the brains of Alzheimer’s sufferers.

When mice were infected by the bacterium, they began to show increased tau protein and tangles, which are characteristic of the mental deterioration of people with early stage dementia.

The research has even triggered false internet claims that “you can catch Alzheimer’s”!

But a closer reading of the research shows that this is a small a scale study, involving lab tests on brain tissue and on mice. These types of study are both useful and necessary as early studies, but not necessarily conclusive. And a link between gum disease and Alzheimer’s doesn’t necessarily mean it causes Alzheimer’s. Correlation is not causation!

What is true, however, is that inflammation in the brain is definitely present in Alzheimer’s patients and gingivitis is an inflammatory disease – all diseases ending in ‘-itis’ are.

At this stage, the safe conclusion is to reduce pro-inflammatory foods in your diet and increase your intake of anti-inflammatory foods and supplements.

Improving on the MIND Diet

Add CURCUMIN/TURMERI

Recent research shows that curcumin (the active ingredient in turmeric) may help prevent the accumulation of plaques that build up in the brains of Alzheimer’s patients – and which interfere with communication between brain cells. Indeed, curcumin activates hundreds of genes that are anti-inflammatory and neuro (brain) protective.

How you can avoid Alzheimer's NutriShield Multi Vitamins and Minerals

Add BETAINE

There is also recent evidence, published in 2019 in the European Journal of Pharmacology, that a nutrient called betaine could have an important preventative role to play.

The researchers state: “betaine is the first potential medicine that can act preventively, instead of just easing the symptoms”. 

It’s important to qualify that this very recent study was on mice and needs to be confirmed in humans – but the report does state that betaine “significantly improves memory and oxidative stress in mice, which indicates that a new AD (Alzheimer’s Disease) medicine might have been found”.

Since we know that betaine also lowers heart disease risk, it is certainly worth including betaine rich foods in your diet (like seafood and wheatgerm) and betaine should be included in a health supplement that aims for brain health.

Add MULTI-STRAIN PROBIOTICS

Probiotics – ‘good’ bacteria – might improve brain function in existing Alzheimer’s patients.  A 2016 study published in Frontiers in Aging Neuroscience reported on 60 Alzheimer’s patients who drank milk that included four probiotic bacteria species for 12 weeks.

The strains were Lactobacillus acidophilus, Lactobacillus casei, Bifidobacterium bifidum, and Lactobacillus fermentum.

There was a ‘statistically significant’ improvement of cognitive function compared with those who drank regular milk.

How you can avoid Alzheimer's NutriShield Multi Vitamins and Minerals

Although researchers do not yet know exactly how gut bacteria influence behaviour or brain function, one theory is that a leaky gut may allow compounds to pass into the blood stream that harm the brain.

By reducing the permeability of the intestinal walls, certain probiotics like Lactobacillus and Bifidobacterium may help prevent this leakage.

It might, therefore, be worth considering a multi-strain probiotic as part of an overall programme to cut the risk of Alzheimer’s.

A Best of the Best Eating Plan

At the end of this article is an eating plan that improves even on the MIND Diet, in that it includes curcumin, betaine and other specifically neuro-protective foods and nutrients.

BUT if you’re trying to get all the nutrients you need by eating only regular food, you may find it difficult. For instance, the number of daily portions of fruits and vegetables in the MIND studies is considerably higher than a simple 5-a-day recommendation.

Indeed, both the American Cancer Society and University College London in a recent huge study conclude that the ideal intake is 9-10 portions of fruits and vegetables a day – plus 2-3 portions of oily fish a week.

At these levels your intake of vitamins, minerals and flavonoids ensures that your blood chemistry becomes seriously protective against age-related illness generally, and dementia in particular.

How you can avoid Alzheimer's NutriShield Multi Vitamins and Minerals

For most people 70 portions of fruit and veg a week is not achievable. Consequently, I believe that people over the age of 50 – who do not generally absorb nutrients as well as younger people – should take a supplement.

That supplement should include flavonoids, which are as important to health as vitamins and minerals. It should also include curcumin, betaine, Omega 3, and the nutrients that promote positive gene expression – like lutein, lycopene, beta carotene, extra B vitamins and vitamin D.

A simple one-a day multivitamin just isn’t enough.

Modified MIND Diet plus NutriShield health supplement

The one-page summary of the ideal, enhanced MIND diet therefore includes a health supplement called NutriShield Premium, which supplies all these extra nutrients. It was originally designed by Dr Paul Clayton, former Chair of the Forum on Food and Health at the Royal Society of Medicine. And – full disclosure – it is a supplement we created in response to the research on healthy ageing and brain health.

How you can avoid Alzheimer's NutriShield Multi Vitamins and Minerals

Unlike most supplements, NutriShield doesn’t just contain the basic RDA (Recommended Daily Allowance) amounts of vitamins and minerals, which only prevent outright deficiencies. Instead, it’s designed to provide you daily with the wide range and high level of nutrients found in the very healthiest diets.

You can download the plan free here.

How you can avoid Alzheimer's NutriShield Multi Vitamins and Minerals

How you can avoid Alzheimer's NutriShield Multi Vitamins and Minerals

This article was written by Colin Rose, a Senior Associate Member of the Royal Society of Medicine, who has been writing on science for 40 years.


If you found this article helpful and believe it can help others who are concerned to help prevent dementia, then please share it. You can also follow me through the icons below.

How you can avoid Alzheimer's NutriShield Multi Vitamins and MineralsHow you can avoid Alzheimer's NutriShield Multi Vitamins and MineralsHow you can avoid Alzheimer's NutriShield Multi Vitamins and Minerals

How you can avoid Alzheimer's NutriShield Multi Vitamins and Minerals
Register now for a free monthly e-newsletter on the latest in nutrition and health research.


How you can avoid Alzheimer's NutriShield Multi Vitamins and Minerals

Dr Paul Clayton designed NutriShield as a comprehensive health supplement with OPTIMUM levels of essential nutrients. See more detail elsewhere on this site or click on the button.


How you can avoid Alzheimer's NutriShield Multi Vitamins and Minerals

Dr Paul Clayton’s best-selling book Health Defence is available from booksellers.

Read it here online or see the website www.healthdefence.com for excerpts and links to buy direct from the publisher.


How you can avoid Alzheimer's NutriShield Multi Vitamins and Minerals

See online here for delicious recipes from the Health Defence Cookbook incorporating healthy foods featuring in a Mediterranean Diet.


References:

MIND diet associated with reduced incidence of Alzheimer’s disease; Morris MC et al, Alzheimers Dement. 2015 Sep;11(9):1007-14.

Involvement of GAT2/BGT-1 in the preventive effects of betaine on cognitive impairment and brain oxidative stress in amyloid β peptide-injected mice. Ibi, D, Tsuchihashi A, Nomura T & Hiramatsu M. (2019). European Journal of Pharmacology842, 57-63.

Exercise training increases size of hippocampus and improves memory. Sayal N (2015) Annals of Neurosciences, 22(2). doi:10.5214/ans.0972.7531.22

Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. Gomes AP et al, Cell. 2013 Dec 19;155(7):1624-38. doi: 10.1016/j.cell.2013.11.037.

Betaine in human nutrition; Stuart AS Craig The American Journal of Clinical Nutrition, Volume 80, Issue 3, November 2004, Pages 539–549

Nutrition and the Risk of Alzheimer’s Disease; Nan Hu et al; Biomed Res Int. 2013: 524820.

Link: ghr.nlm.nih.gov/gene/BDNF

Porphyromonas gingivalis in Alzheimer’s Disease brains: Evidence for disease causation and treatment with small-molecule inhibitors; Stephen S. Dominy et al; Science Advances, 23 Jan 2019: Vol. 5, no. 1, eaau3333


Clear out ‘zombie cells’ and live healthier, longer

Clear out ‘zombie cells’ and live healthier, longer NutriShield Multi Vitamins and Minerals

And do it with food, not expensive pharma medicines

Investors in biotech companies are putting billions into a new category of drugs that promise to extend the number of years you can stay healthy – and improve the quality of life in later years.

Dr Richard Miller is a leading gerontologist at the University of Michigan. In an article in New Scientist headed ‘The Age of Living Younger’, he states:

“We have proven you can slow the ageing process using drugs”.

He’s right. But Big Pharma’s expensive drugs are not the only – or even the best way. Because you can get the same result with nutrition and food.

Why does so much illness appear age-related?

The incidence of almost every debilitating chronic disease – heart disease, stroke, dementia, cancer, arthritis, vision impairment – increases suddenly around the age of 60.

But it is not related to the passing of years. It is related to accumulated, unrepaired damage to DNA and to the cells that make up our tissues and organs – causing those organs to gradually fail. The damage accumulates because the body’s cell repair mechanisms stop working properly. Prevent, limit or even reverse that damage, by boosting cell repair mechanisms, and you stay healthier for longer. But how?

Toxic dead ‘zombie’ cells need to be cleared

The trillions of cells in your body are continually turning over. They replicate and ultimately die. Indeed, an estimated 50 billion die each day!  A normal cell death occurs through a process called apoptosis, and those dead cells are usually cleared away.

Clear out ‘zombie cells’ and live healthier, longer NutriShield Multi Vitamins and Minerals

But occasionally the dead cells or debris from the dead cells is not cleared away. These are called senescent cells – cells that have suffered irreversible damage, but which have not been eliminated from the body.

Scientists sometimes refer to them as them junk or zombie cells.

Very recent research by Judith Campisi at the Buck Institute for Ageing shows that these senescent cells secret a cocktail of damaging chemicals that poison surrounding tissues and cause chronic inflammation.

We know inflammation underlies almost all age-related diseases and the Buck Institute explains how that inflammation occurs and directly links senescent cells to ageing itself and to cancer.

Lynne Cox, a biochemist at Oxford University, underlines the threat: “Senescent cells are very bad for you – they destroy the tissues around them”.

Even a small number of uncleared senescent cells trigger problems – just as a rotten strawberry in a punnet can cause the rest to go bad.

(Hold that analogy in your mind, as it will have special significance as we unravel this latest science).

The huge cost of senescent cells

A result of this damaging sequence – senescent cells poison surrounding tissues, which causes chronic inflammation, which causes multiple later life illnesses – is that the average person will live the last 12 – 18 years of their life with some sort of health issue and increasingly on medication.

This is not only distressing for the individual, but a huge cost for society. 80% of healthcare costs in the US are linked to later-life degenerative disease! It’s similar in the UK where the annual spend on healthcare is £2,892 for every man, women and child and most of that is spent on later life.

So, a drug that clears senescent cells and therefore extends healthy life span could literally save trillions.

You are likely to live a somewhat longer life – say typically to around 90
– but, importantly, stay healthy, vigorous and productive until your final year or two. As one researcher put it, perhaps too bluntly,

“We are not trying to fill care homes with geriatrics, we are trying to make sure you live actively and well to enjoy your pension to the full!”

You can see why bio-tech investors are so excited. But our interest is in doing this without Big Pharma’s expensive, patented pills.

How you can clear away senescent “zombie” cells

Clear out ‘zombie cells’ and live healthier, longer NutriShield Multi Vitamins and Minerals

If you take senescent cells from an old mouse and transplant them into a young mouse, it ages prematurely and suffers age-related diseases.

The reverse is true. In 2011 researchers at the Mayo Clinic used a drug to clear senescent cells from aged mice – and it significantly extended the time they were disease-free and enabled them to function as young mice.

Removing senescent cells “jump starts tissues’ natural repair mechanisms” as a Johns Hopkins researcher puts it.

Other studies in 2016 and 2018, including at Newcastle University, showed that a range of illnesses – from simple frailty to heart disease to osteoporosis to dementia and even to osteoarthritis – was halted or even reversed by clearing senescent cells.

As a leading researcher put it, we are now seeing:

“ … how multiple diseases of ageing are being caused buy a single underlying cause”.

It is a genuine breakthrough in understanding how healthy lifespan can be extended.

James Pickett, is head of research at the Alzheimer’s Society, and was not involved in the Mayo study. His comment:

“There hasn’t been a new dementia drug in 15 years, so it’s exciting to see the results of this promising study.”

The importance of “senolytics”

So how do we clear away senescent cells?  The answer is with senolytics – defined as molecules that seek out, destroy and eliminate senescent cells.

There are drugs that do this – like dasatinib, navitoclax and possibly the diabetes drug metformin – but none appears to work very well on their own, without being coupled with flavonoids.

Clear out ‘zombie cells’ and live healthier, longer NutriShield Multi Vitamins and Minerals

Flavonoids are a class of nutrients in fruits and vegetables that are as important to health as the vitamins and minerals that fruits and veggies also provide.

They include the pigments in plants – like resveratrol (found in grape skin, red wine, blueberries and bilberries), quercetin (found in red onions, apples, green and black tea and grapes), beta carotene, lutein and lycopene (the red pigment found in tomatoes).

Many flavonoids are linked to an anti-cancer effect, as well as being senolytic.

A flavonoid with powerful senolytic action – fisetin

But the most powerful flavonoid with senolytic activity appears to be a little-known pigment called fisetin – found in strawberries – at a level that’s 6 times higher than in the next fruit, which is apples.

Clear out ‘zombie cells’ and live healthier, longer NutriShield Multi Vitamins and Minerals

A lead researcher at the Institute on the Biology of Ageing and Metabolism at the University of Minnesota told Newsweek magazine:

“We’re looking for drugs that can kill these damaged senescent cells that are very toxic to our bodies and accumulate as we get older. It turns out that fisetin is a natural product that we were able to show very selectively and effectively kills these senescent cells.”

You’ll note that she didn’t suggest you just loaded up with strawberries. Unfortunately the default reaction from most researchers is to make a natural product into a drug!!

Another proven senolytic – nicotinamide form of Vit B3

Another proven senolytic is nicotinamide, a form of vitamin B3, which unlike niacin, does not cause flushing.  Nicotinamide creates a blood chemical called NAD+, which clears DNA damage from especially mitochondrial cells – the tiny ‘energy factories’ in our cells. That should, in turn, improve energy levels.

There are already supplements on the market that combine resveratrol, quercitin and nicotinamide. But they are jumping the gun. Partly because research on quercetin and resveratrol as senolytics, on their own, is not conclusive. And partly because senolytics are not the whole story.

All-round cellular spring cleaning

To create a truly comprehensive plan that will clear senescent cells and therefore prolong health, we need to include what are called mTOR inhibitors. O.K. it’s a mouthful – but stay with me!

The mTOR pathway

mTOR is a pathway within your cells that regulates the life cycle of that cell – its growth, repair and natural death. The science is rather complicated, but the key is this.

  • mTOR senses your nutrient intake and when it senses adequate nutrients, the cell will replicate.  
  • When it is suppressed, then rather than replicating, the cell goes into repair mode.
  • When it is over-stimulated it can promote excess growth and even tumours.

So it’s a finely balanced cycle. And sometimes you’ll want to suppress or down-regulate mTOR to ensure your cell repair mechanisms are working properly.

One way to suppress mTOR is calorie restriction, which we know improves cell repair and makes organisms live longer. Which is why some people fast. But starving yourself is hardly the most attractive way to live longer!

Down-regulating mTOR to up-regulate cell repair

The key fact to remember is that to upregulate cell repair – thereby boosting health and longevity – you need to down-regulate or damp down the mTOR pathway.

Assuming fasting is not your option, there are drugs that do this – possibly including metformin. Exercise also helps suppress the mTOR pathway. But again, certain nutrients and food compounds do it.

So why risk the drugs?

Some of the most powerful, natural, mTOR inhibitors include curcumin, EGCG (an ingredient in green tea), Omega 3, olive oil, indoles (a compound in broccoli, sprouts and kale), genistein (a compound in soy with anti-cancer credentials), grapeseed extract, fisetin (again) and quercetin.

Clear out ‘zombie cells’ and live healthier, longer NutriShield Multi Vitamins and Minerals

You should note that there are also factors that can dangerously over-stimulate the mTOR pathway, notably excess protein. This makes sense – if mTOR senses excess nutrition intake, it may go into cell replication overdrive and cancer is marked by unrestricted cell replication.

Garbage disposal for old cells

The final piece of the jigsaw is that down-regulated mTOR also cleans out dead cell debris, a process called autophagy – which literally means “self-eating”.

So, although senolytic activity and autophagy are not exactly the same, you want both of them working properly to do a frequent ‘internal spring clean’. Or as one researcher puts it – “to act like a garbage disposal system for old cells”.

The summary so far

  • Cleaning out senescent cells that are dead, but still present in the body, prevents them causing toxicity which leads to inflammation and thus to many diseases that are related to age, but not caused by ageing. That includes osteoarthritis, cancer and Alzheimer’s.
  • Damping down mTOR activity encourages the process of cell repair, which otherwise becomes weaker over time. It also ensures that ‘zombie’ cells are cleared away.
  • You can liken both processes – which are vital for reducing the risk of cancer, heart disease, dementia and even arthritis, and for increasing the years in which you remain healthy – to a regular spring clean.
  • There are natural compounds that do this – including nicotinamide (vitamin B3), the flavonoids in strawberries, blueberries, turmeric (curcumin), green tea, grapeseed, green leafy vegetables, onions and garlic.

What you can do with supplements

I need to make a disclosure at this point.

I have been researching nutrition and health for over 30 years. Some years ago, when I was 60, I worked with the then Chair of the Forum on Food and Health at the Royal Society of Medicine, Dr Paul Clayton, to create a comprehensive health food supplement.  Because we knew from many surveys that a simple vitamin and mineral pill made little difference.

The multi-capsule daily health food supplement is called NutriShield.

  • It is high in antioxidants and anti-inflammatory nutrients, because we knew that oxidative free radical damage and inflammation were key causes of chronic age-related illness.
  • It includes nutrients known to boost the immune system as we know immune function can decline with age.
  • It includes nutrients that help express or ‘turn on’ genes that lead to improved health – nutrients like lutein, betaine, omega 3, folate (folic acid), genistein, curcumin and beta carotene.
  • NutriShield also includes high levels of flavonoids and key vitamins and minerals – levels found in the diets of longevity hot-spots around the world called blue zones. But these levels are hard to achieve in a typical Western diet.

It’s only recently that the importance of clearing out toxic senescent cells has been uncovered.

However, we knew about the need to down-regulate mTOR and already had many of the mTOR down-regulators in NutriShield – nutrients like curcumin, green tea, genistein, Omega 3 and grapeseed.

We included high levels of flavonoids (and nicotinamide) because they are found diets of people who stay healthy the longest. We now know they are also senolytics. The potency of fisetin as a senolytic has only recently come to prominence, so it is not yet included in NutriShield.

Add strawberries every 2 weeks

An encouraging thing from the senolytic research is that it appears you don’t need to take action every day – an occasional, probably bi-weekly, clear-out seems to work very well.

So why not add a large bowl of strawberries at least once every two weeks? That’s certainly no hardship for most people! And canned or frozen are fine out of season.

Try this healthy eating plan – it’s simple and effective

Finally, there is a PDF of a healthy eating plan you can download here.

It combines the best health and nutrition advice from amongst others, Harvard Health, UCLA, University College London and the American Cancer society.

The combination of NutriShield and the eating plan will tackle those zombie cells too!


Clear out ‘zombie cells’ and live healthier, longer NutriShield Multi Vitamins and Minerals

This article was written by Colin Rose, a Senior Associate Member of the Royal Society of Medicine, who has been writing on science for 40 years.


If you enjoyed this article, please share it with family and friends. You can follow us on Facebook or Twitter for daily headline health tweets.

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Clear out ‘zombie cells’ and live healthier, longer NutriShield Multi Vitamins and Minerals
Register now for a free monthly e-newsletter on the latest in nutrition and health research.


Clear out ‘zombie cells’ and live healthier, longer NutriShield Multi Vitamins and Minerals

Dr Paul Clayton designed NutriShield as a comprehensive health supplement with OPTIMUM levels of essential nutrients. See more detail elsewhere on this site or click on the button.


Clear out ‘zombie cells’ and live healthier, longer NutriShield Multi Vitamins and Minerals

Dr Paul Clayton’s best-selling book Health Defence is available from booksellers.

Read it here online or see the website www.healthdefence.com for excerpts and links to buy direct from the publisher.


Clear out ‘zombie cells’ and live healthier, longer NutriShield Multi Vitamins and Minerals

See online here for delicious recipes from the Health Defence Cookbook incorporating healthy foods featuring in a Mediterranean Diet.


References:

Cellular Senescence: The Sought or the Unwanted? ; Sun, Y., Coppé, J. P., & Lam, E. W. F. Trends in Molecular Medicine. (2018).

Senescence in health and disease. He S, Sharpless NE. Cell. 2017; 169: 1000-1011

Cellular senescence and its effector programs. Salama R. et al; Genes Dev. 2014; 28: 99-114

New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, Yi Zhu, et al, Aging (Albany NY) 2017

Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. Gomes AP et al, Cell. 2013 Dec 19;155(7):1624-38. doi: 10.1016/j.cell.2013.11.037.

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