Grapeseed fights cancer

The extraordinary secret of the seeds in grapes

Grapeseed fights cancer NutriShield Multi Vitamins and MineralsThe lifetime risk of getting cancer is about 53% for men and 48% for women. So good news on ways to cut that risk is important to every one of us.

Grape seeds or grapeseed extract may not be your first thought as part of a cancer preventative strategy, but many studies (fully referenced below) show that the seeds of grapes have important anti-cancer properties including against breast, prostate, melanoma, pancreatic and colon cancer.

The reason grapeseed extract is exciting scientists in the field is that it contains compounds have been found to inhibit the mechanisms behind cancer in multiple ways. These compounds include procyanidins, gallic acid and catechins.

Grapeseeds contain multiple cancer-fighting compounds

A multiple approach to help prevent or treat cancer is highly desirable, because most chemotherapy drugs tackle only one or two of the mechanisms to try to stop cancer spreading (metastasising).

Moreover, different people react in different ways to chemotherapy – as they do to nutrients in food. So the more interventions that can be used to inhibit the processes by which cancer originates, the more likely one of them is to be effective.

The University of Colorado has been studying the ability of grapeseed extract to kill cancer cells for over 17 years. This research, together with other work at the University of Maryland Medical Center, shows that the procyanidins in grapeseed extract have been found to have three key anti-cancer mechanisms:

  1. They suppress cell-signalling. Signalling is key to the ability of cancer cell to grow and spread, so suppressing it helps stop that growth.
  2. They damp down inflammation which otherwise encourages the spread of cancer cells.
  3. They stimulate cell death – what is called apoptosis. Encouraging cancer cells to die is essential, because cancer involves mutated cells that proliferate and refuse to die when they should.

Grapeseed fights cancer NutriShield Multi Vitamins and Minerals

Grapeseed helps inhibit colon cancer

Colon and bowel cancers are the third most deadly form of cancer. Most develop from polyps in the intestine.

Research published in the specialist cancer journal Neoplasia has found that Grape Seed Extract (GSE) can cut the number of large polyps by as much as 70%.

It has also been shown to reduce both the formation and the spread of cancer cells by over 80% and to help suppress tumour cells.

Even more importantly, grapeseed extract has been shown to suppress colon cancer stem cells – which is central to eliminating a cancer.

Grapeseed helps inhibit prostate cancer

Grapeseed also includes gallic acid and this compound appears very effective in decreasing the proliferation and size of prostate tumours. Studies show that the effect is dose-dependent – starting at 50mg a day as a daily preventative dose to as high as 200mg a day as treatment.

Other compounds in grapeseed help prevent angiogenesis – the growth of blood vessels that tumours need to maintain themselves and grow. If this blood supply is cut off, the tumours can shrink. Other research shows that a compound in soy isoflavones called genistein can do the same.

Of course, these desirable effects are not limited to prostate cancer – so grapeseed extract is indicated as part of an overall anti-cancer strategy.

Grapeseed helps inhibit breast cancer

There is evidence, from a study published in Breast Cancer Research Treatment, that grapeseed can enhance the effect of one of the common breast cancer chemotherapy drugs called doxorubicin (brand name Adriamycin).

Additionally, grapeseed’s strong anti-oxidant effect has been shown to protect and maintain heart muscle. This is important, as damage to the heart can be a side-effect of breast cancer therapy.

Grapeseed helps inhibit ALL cancers

Grapeseed extract has another very important anti-cancer mechanism – not just for breast, but all cancers. This includes pancreatic cancer, which has a low survival rate and is notoriously difficult to treat.

Grapeseed extract has been shown to reduce strongly the damaging effect of protein enzymes called MMPs (Matrix Metallo-Proteinases).

MMPs are important proteins for normal wound healing. BUT in excessive numbers, they are highly damaging and can literally chew through the matrix of cells that form the outer ‘mesh’ tissue walls of internal organs. The resulting breach allows cancer cells to spread or metastasise and invade other organs.

Grapeseed extract appears from research to be able to stop or slow the damage from MMPs and therefore help inhibit or even prevent cancer cells from spreading.

Other compounds that appear able to do this are curcumin and the flavonoids in dark-coloured berries such as bilberry and blackcurrants – and the catechins in green tea.

So combining all these compounds is a logical, natural, defensive strategy, as we do in the supplement NutriShield.

High doses for treatment alongside cancer drugs

If cancer has actually presented, however, the research indicates that high doses of grapeseed extract are needed – in conjunction with conventional cancer drugs. Some clinics are using doses as high as 1,200mg of grapeseed extract a day plus 1,000mg of curcumin taken with an oil source like Omega 3 for better bioavailability.

Brain health benefits of grapeseed

Grapeseed fights cancer NutriShield Multi Vitamins and Minerals

Grapeseed extract is both a powerful anti-oxidant and an anti-inflammatory. There is a lot of fatty tissue in the brain and therefore it is vulnerable to oxidation or free radical damage – in rather the same way as fats will oxidise (go rancid) in the presence of air/oxygen.

In animal experiments, grapeseed extract was found to inhibit free radical damage to the brain and help prevent loss of cognitive ability – even in the presence of a high fat diet.

Over the last few years, brain researchers have identified a key element in degenerative brain diseases as being the interaction in brain cells between inflammation and what is called excitotoxicity.

Excitotoxity is a highly complex process, but is essentially the over-activity of certain ‘excitatory amino acids’ including glutamate, leading to neuron death and potential dementia.

What is important is that studies show that grapeseed extract helps inhibit both inflammation and excitotoxicity. This may be why a study showed that patients who had been taking grapeseed extract prior to a stroke suffered less memory impairment.

Grapeseed fights cancer NutriShield Multi Vitamins and MineralsIn one other important study, researchers concluded that grapeseed extract – along with other flavonoids like curcuminoids, green tea catechins, apigenin (found in parsley and onions) and luteolin (found in celery, thyme and chamomile tea) – can reduce the level and effect of age-related changes in the brain.  These flavonoids appear to act against the brain-toxic sticky protein called beta-amyloid and also tau protein tangles – both characteristics of dementia and especially Alzheimer’s.

It s for these reasons that there are now human trials ongoing using grapeseed extract as a specific natural adjunct treatment for Alzheimer’s.

The brain benefits of grapeseed extract are especially important for diabetic patients who are at increased risk of neural damage. Indeed, the US Government’s National Center for Complementary and Integrative Health (NCCIH) suggests the use of grapeseed in:

“… complications related to diabetes, such as nerve and eye damage; vision problems, such as macular degeneration (which can cause blindness); swelling after an injury or surgery; cancer prevention; and wound healing.”

Finally, the multiple health benefits of grapeseed extract extend to help lowering blood pressure in overweight people and to improved heart function.

Start to take preventative action against cancer early

Although cancer appears mainly a disease of older people – most cases are first reported in over 65s – it is a slowly developing disease. So the first stages may be occurring as much as 10-15 years before it manifests itself.

Therefore, the time to take preventative action is in the very early 50s. As you will have seen, a grapeseed extract supplement is a logical part of that action. But it’s only a part, as there are many other actions you can take.

We have created a comprehensive report on the very best ways to cut the risk of cancer – and you can read it here: Reduce cancer risk and maximise your health span.

It is on the basis of the research outlined in this article that we have included grapeseed extract, green tea extract, soy isoflavones and curcumin in our over 50s daily health supplement NutriShield Premium.


If you enjoyed this article, please share it with family and friends. You can follow us on Facebook or Twitter for daily headline health tweets.

Grapeseed fights cancer NutriShield Multi Vitamins and Minerals And register now for a free regular e-newsletter on the latest in nutrition and health research.

Dr Paul Clayton designed NutriShield as a comprehensive healthGrapeseed fights cancer NutriShield Multi Vitamins and Minerals supplement with OPTIMUM levels of essential nutrients including grapeseed extract. See more detail elsewhere on this site or click on the button.

Grapeseed fights cancer NutriShield Multi Vitamins and MineralsDr Paul Clayton’s best-selling book Health Defence is available from bookstores or from Uni-Vite Healthcare here.

A free summary report and the opportunity to read the book online is available here.

See online here for delicious recipes from the Health Defence Cookbook  incorporating healthy foods featuring in a Mediterranean Diet. Grapeseed fights cancer NutriShield Multi Vitamins and Minerals


Dietary flavonoids: Role of (-)-epicatechin and related procyanidins in cell signalling. Fraga CG, Oteiza PI.  Free Radic Biol Med. 2011 Aug 15;51(4):813-23. doi: 10.1016/j.freeradbiomed.2011.06.002. Epub 2011 Jun 12.

Grape seed proanthocyanidins inhibit the proliferation, migration and invasion of tongue squamous cell carcinoma cells through suppressing the protein kinase B/nuclear factor-κB signaling pathway. Ninggang Yang, Jing Gao, Xin Cheng, Cuilan Hou, Yaya Yang, Yanxin Qiu, Mengrou Xu, Yuan Zhang and Shuangsheng Huang. Int J Mol Med. 2017 Dec; 40(6): 1881–1888.

Fractionation of grape seed extract and identification of gallic acid as one of the major active constituents causing growth inhibition and apoptotic death of DU145 human prostate carcinoma cells. Veluri R, Singh RP, Liu Z, Thompson JA, Agarwal R, Agarwal C. Carcinogenesis. 2006 Jul;27(7):1445-53. Epub 2006 Feb 10.

Dietary Feeding of Grape Seed Extract Prevents Intestinal Tumorigenesis in APCmin/+ Mice. Balaiya Velmurugan, Rana P Singh, Nidhi Kaul, Rajesh Agarwal and Chapla Agarwal. Neoplasia. 2010 Jan; 12(1): 95–102.

Dietary grape seed extract ameliorates symptoms of inflammatory bowel disease in IL10-deficient mice. Wang H, Xue Y, Zhang H, Huang Y, Yang G, Du M, Zhu MJ. Mol Nutr Food Res. 2013 Dec;57(12):2253-7. doi: 10.1002/mnfr.201300146. Epub 2013 Aug 21.

Synergistic anti-cancer effects of grape seed extract and conventional cytotoxic agent doxorubicin against human breast carcinoma cells. Sharma G, Tyagi AK, Singh RP, Chan DC, Agarwal R. Breast Cancer Res Treat. 2004 May;85(1):1-12.

Grape seed extract inhibits the growth of prostate cancer PC-3 cells. Huang TT, Shang XJ, Yao GH, Ge JP, Teng WH, Sun Y, Huang YF. 2008 Apr;14(4):331-3.

Grape seed extract induces apoptotic death of human prostate carcinoma DU145 cells via caspases activation accompanied by dissipation of mitochondrial membrane potential and cytochrome c release. Chapla Agarwal, Rana P. Singh, Rajesh Agarwal. Carcinogenesis, Volume 23, Issue 11, 1 November 2002, Pages 1869–1876,

Molecular mechanisms of excitotoxicity and their relevance to pathogenesis of neurodegenerative diseases; Xiao-xia Dong, Yan Wang and Zheng-hong Qin. Acta Pharmacol Sin. 2009 Apr; 30(4)

Multi-targeted therapy of cancer by genistein. Sanjeev Banerjee, Yiwei Li, Zhiwei Wang, and Fazlul h. Sarkar. Cancer Lett. 2008 Oct 8; 269(2): 226–242.

Anticancer and Cancer Chemopreventive Potential of Grape Seed Extract and Other Grape-Based Products. Manjinder Kaur, Chapla Agarwal, and Rajesh Agarwal. J Nutr. 2009 Sep; 139(9): 1806S–1812S.

Grape seed extract suppresses lipopolysaccharide-induced matrix metalloproteinase (MMP) secretion by macrophages and inhibits human MMP-1 and -9 activities. La VD, Bergeron C, Gafner S, Grenier D. J Periodontol. 2009 Nov;80(11):1875-82. doi: 10.1902/jop.2009.090251.

Grape Seed Extract and Brain Cell Rejuvenation.  Yoo DY, Kim W, Yoo KY, Lee CH, Choi JH, Yoon YS, Kim DW, Won MH, Hwang IK. Phytother Res

Brain Bioavailability of Grape Seed Polyphenols. Mario G. Ferruzzi, Jessica K. Lobo, Elsa M. Janle, Naomi Whittaker, Bruce Cooper, James E. Simon, Qing-Li Wu, Cara Welch, Lap Ho, Connie Weaver and Giulio M. Pasinetti. Journal of Alzheimer’s Disease

Grape Seed Extract Reduces Alzheimer’s Plaque. Jun Wang, Lap Ho, Wei Zhao, Kenjiro Ono, Clark Rosensweig, Linghong Chen, Nelson Humala, David B. Teplow, and Giulio M. Pasinetti. The Journal of Neuroscience

Role of grape seed polyphenols in Alzheimer’s disease neuropathology. Giulio Maria Pasinetti and Lap Ho. Nutr Diet Suppl. 2010 Aug 1; 2010(2): 97–103.


Top 7 anti-inflammatory foods

Nutrients which reduce chronic inflammation

The biggest single risk to your long term health is what’s called ‘chronic sub-clinical inflammation’. It’s a continuous, damaging level of inflammation of body tissues that tends to build up as we age, but is normally not noticeable. So it’s an insidious, but major threat.

How major? VERY major!

“Inflammation is an underlying contributor to virtually every chronic disease … along with major killers such as heart disease, cancer and stroke.”

Scientific American

“Inflammatory factors predict virtually all bad outcomes in humans … having heart attacks, having heart failure, becoming diabetic … becoming fragile in old age … cognitive function decline, even cancer to a certain extent.”

Russell Tracy, Professor of Pathology and Biochemistry, University of Vermont College of Medicine

“… we can now seriously start thinking about inflammation as a potential driver of accelerated ageing and how we might be able to delay it.”

Institutes for Ageing and Cellular Medicine at Newcastle University

Chronic versus acute inflammation

We are normally familiar with inflammation as the sign of a good immune response. We suffer a cut or sting and the area becomes inflamed – which is a sign that your immune system is working to bring healing white blood cells like neutrophils and macrophages to cure the problem.

But that type of inflammation is called acute inflammation. The cause and the cure are both short term.

The problem arises when damage occurs within your body’s tissues, but that damage is not completely cleared by the immune response. That sets up a low level of continuous, long term chronic inflammation that damages cells and tissues.

This type of inflammation is a key driver of heart disease, stroke, diabetes, erectile dysfunction and indeed any diseases ending in  ‘itis’ – which means inflammatory.  So arthritis, colitis, sinusitis and many, many, more.

It also creates an environment that more easily allows the spread of cancerous cells.

Top 7 Anti-inflammatory foods

Therefore lowering the level of inflammation is a vital contribution to your long term health. So make sure the following feature regularly in your diet:

  1. Salmon (or other oily fish)Top 7 anti-inflammatory foods NutriShield Multi Vitamins and Minerals

    Salmon contains Omega-3 fatty acids. Studies show that people who have a higher intake of Omega 3 suffer fewer heart problems because Omega 3 reduces inflammation and helps lower cholesterol . The American Heart Association suggests you eat oily fish like salmon, tuna, mackerel, sardines, trout and herring at least 2-3 times a week.

  2. BroccoliTop 7 anti-inflammatory foods NutriShield Multi Vitamins and Minerals

    Broccoli is a cruciferous vegetable, part of a group including cabbage, Brussels sprouts and cauliflower. They are high in a plant compound called glucosinolates, which are powerful antioxidants and anti-inflammatories. Population studies show that eating a diet high in cruciferous vegetables is linked to a lower risk of cancer.

  3. BlueberriesTop 7 anti-inflammatory foods NutriShield Multi Vitamins and Minerals

    Blueberries contain significant amounts of polyphenols and carotenoids.It is the polyphenol and carotenoid content of plant foods, not just their vitamins and minerals, which makes fruits and vegetables so valuable to your health.

    Carotenoids are largely concentrated in the skin and colouring of fruits like blueberries, raspberries, blackcurrants and strawberries – and they and polyphenols have potent antioxidant and anti-inflammatory effects, which researchers strongly believe helps prevent cancer and cardiovascular disease.

    The carotenoids lutein and lycopene are known to prevent and repair the DNA and cellular damage done by free radicals – which, unchecked, can trigger cancer.

  4. KaleTop 7 anti-inflammatory foods NutriShield Multi Vitamins and Minerals

    Kale is a great source of vitamins A, C, and K, and the minerals calcium, iron, magnesium and potassium. Kale, like broccoli, contains glucosinolates, plus the carotenoids lutein and zeaxanthin. These carotenoids have been shown to protect vision and lower your risk of developing cataracts and macular degeneration. A similar anti-inflammatory superfood is spinach. It too contains lutein, vitamin K2 (which is heart healthy), folic acid, and beta carotene. Research shows that people who eat a largely plant based diet, including these leafy green vegetables, have a significantly reduced risk of cancer and heart disease.

  5. Carrots and sweet potatoes
    Top 7 anti-inflammatory foods NutriShield Multi Vitamins and Minerals

    Carrots of course contain the carotenoid beta-carotene which your body can convert to vitamin A as needed. Carrots also contain other carotenoids (zeaxanthin and lutein), and these antioxidants help reduce your risk of cancer by shielding your healthy cells from free radical damage. They are also a good source of fibre.

    Sweet potatoes, like other orange-coloured vegetables, are also high in vitamin A and beta-carotene antioxidants and anti-inflammatories. They are also high in fibre and high fibre consumption is linked to lower cancer risk.

  6. Almonds, walnuts and other nutsTop 7 anti-inflammatory foods NutriShield Multi Vitamins and Minerals

    Nuts are very healthy, and you should try to incorporate a handful each day into your diet – either as a snack or on cereals. Eating almonds, walnuts, pecans and Brazils is linked to a lower risk of cardiovascular disease. Walnuts are a great source of protein, vitamin E, minerals and phytochemicals called sterols. They also contain monounsaturated fatty acids (as does olive oil) and heart-healthy Omega-3 fatty acids.

  7. AvocadosTop 7 anti-inflammatory foods NutriShield Multi Vitamins and Minerals

    Avocados are rich in monounsaturated fats, plus they’re a great source of magnesium, fibre, and potassium – all cardio-healthy nutrients.

The combination of the vitamins, minerals, carotenoids and polyphenols in these top 7 (ish) foods is the basis of a highly anti-inflammatory diet.

You really are – and will become – what you eat.

Reduce pro-inflammatory foods

But you must also aim to reduce the amount of pro-inflammatory foods in your diet.Top 7 anti-inflammatory foods NutriShield Multi Vitamins and Minerals

Your body uses fatty acids from the food you eat to make the outer membranes of cells and also certain important hormones. Omega 6 fatty acids – found in polyunsaturated plant oils like safflower, sunflower and corn oil and in very many ready meals and processed foods  – are used by the body to produce hormones that promote inflammation.

Omega 3 fatty acids (from oily fish) have the opposite effect – they are used to produce hormones that reduce inflammation.

All this is why University College London recently joined the American Cancer Society in recommending 9-10 portions of fruits and vegetables a day. Plus the 2-3 portions of oily fish.

Of course it is rather a challenge for most people – so an anti-inflammatory nutritional supplement like NutriShield that includes a range of polyphenols, flavonoids and carotenoids plusOmega 3, as well as an optimised level of vitamins and minerals, can be a good choice to ‘fill in the gaps’.

If you want to read more about this topic you can download a free e-book called “Inflamm-ageing” below.

Top 7 anti-inflammatory foods NutriShield Multi Vitamins and Minerals


If you enjoyed this article, please share it with family and friends. You can follow us on Facebook or Twitter for daily headline health tweets.

Top 7 anti-inflammatory foods NutriShield Multi Vitamins and MineralsTop 7 anti-inflammatory foods NutriShield Multi Vitamins and MineralsTop 7 anti-inflammatory foods NutriShield Multi Vitamins and Minerals

Top 7 anti-inflammatory foods NutriShield Multi Vitamins and MineralsAnd register now for a free monthly e-newsletter on the latest in nutrition and health research.

Dr Paul Clayton designed NutriShield as a comprehensive healthTop 7 anti-inflammatory foods NutriShield Multi Vitamins and Minerals supplement with OPTIMUM levels of essential nutrients. See more detail elsewhere on this site or click on the button.

Top 7 anti-inflammatory foods NutriShield Multi Vitamins and MineralsDr Paul Clayton’s best-selling book Health Defence is available from most good bookstores.

See the website for excerpts and links to buy direct from the publisher.

See online here for delicious recipes from the Health Defence Cookbook incorporating healthy foods featuring in a Mediterranean Diet. Top 7 anti-inflammatory foods NutriShield Multi Vitamins and Minerals