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How you can avoid Alzheimer’s

How you can avoid Alzheimer's NutriShield Multi Vitamins and Minerals

Cut your risk by 53% – or more

You can reduce your risk of Alzheimer’s by 53%, according to new research from Harvard University. And by adding just three more common nutrients to their dietary recommendations – you can cut the risk even further.

You’ve probably read that ageing is a risk factor for Alzheimer’s – but that’s not strictly accurate.

What is true, is that you normally accumulate damage to DNA, cells and organs as you age. It is this damage that results in Alzheimer’s – not the passing of the years.

So, the good news is that if you reduce, slow or prevent cell and tissue damage, major new research shows you can more than halve the risk of dementia.

The even better news is that, if you take the preventative action outlined below, you also cut your risk of heart disease and stroke – probably by as much as 80%.

This article was written by Colin Rose, a Senior Associate Member of the Royal Society of Medicine, who has been writing on science for 40 years.

Alzheimer’s facts and figures

A leading cause of death

Dementia is now the Number 1 cause of death in women and the Number 2 in men – according to the UK’s Office of National Statistics in 2017.

That’s because the brain ultimately controls everything – the heart, gastro-intestinal organs, metabolism, etc.  Dementia, therefore, becomes a terminal illness, leading to overall frailty, susceptibility to infections, eating problems, pneumonia and breathing difficulties. And is highly distressing to the individual and family.

70% of people with dementia have Alzheimer’s

About 70% of people with dementia have Alzheimer’s Disease, which involves a gradual decline in cognitive function. Vascular Dementia is caused by restricted blood flow, and therefore oxygen and nutrients, to the brain. It is often linked to high blood pressure, high cholesterol or follows a stroke or heart disease.

Most Alzheimer’s sufferers are over 65

Most people with Alzheimer’s Disease are 65 and older. After the age of 65, when the risk is about 2%-3%, the risk of Alzheimer’s DOUBLES every five years.

After age 85, the risk reaches almost 30% of all adults.

But if you are reading this, and are in your 50s or early 60s, you should note that Alzheimer’s is a stealthy threat. It begins at least 10 years before the symptoms become apparent in everyday behaviour.

So the time to take action is well before 65.

The genetic links are weak, except for those of Afro-Caribbean heritage

The risk of Alzheimer’s is doubled in people of Afro-Caribbean heritage – a genetic link.

Other genetic links are weak, so that someone of other heritage with a parent or grandparent who developed Alzheimer’s is at only slightly higher risk. But, according to the Alzheimer’s Association, “it is estimated that less than 1 percent of Alzheimer’s cases are caused by deterministic genes genes that cause a disease, rather than increase the risk of developing a disease)”.

Strong links with heart disease and stroke

There is a strong link between heart disease, stroke, ED (Erectile Dysfunction) and Alzheimer’s Disease. Because a healthy brain and a healthy heart both need unrestricted blood flow through arteries and blood vessels.

High blood pressure increases risk

For this reason, hypertension or high blood pressure increases the risk of Alzheimer’s

Brain ‘plaques’ and ‘tangles’

Alzheimer’s brains are characterised by ‘plaques’ and ‘tangles’. Plaques consist of dead brain cells and a protein called beta amyloid which is toxic. Tangles are made up of another protein called tau, which becomes abnormal and clumps together leading to neuron cell death and inhibited neural communication.

Noticeable change can take 10 years to show

These changes in the brain may take up to 10 years to become noticeable in behaviour.

Average survival from onset of symptoms is 8.4 years

The average survival time from the onset of symptoms is 8.4 years.

Diabetes increases risk

Diabetes increases the risk – but the development of diabetes can be slowed or prevented with the exact same programme as we discuss below.

Stress, obesity, smoking and alcohol increase risk

Chronic – long-term – stress increases the risk, as do obesity, smoking and high alcohol consumption.

Gum disease may be linked

There also may be a link between a bacterium that causes the gum disease gingivitis and Alzheimer’s.

No drugs yet that prevent or slow Alzheimer’s

There are no drugs yet that prevent or slow Alzheimer’s.

MIND Diet lowers Alzheimer’s risk by 53%

The MIND Diet was developed by Rush University and the Harvard School of Public Health in 2015. It stands for the Mediterranean/Dash Intervention for Neurodegenerative Delay – and combines the best of what were previously the world’s two most studied diets.  

These were the well-known Mediterranean Diet and the DASH Diet – the latter stands for Dietary Approaches to Stop Hypertension, developed at Harvard University.

The MIND Diet emphasises ‘brain foods’ that improve focus and memory – foods like berries (blueberries, raspberries, strawberries etc), lots of vegetables, green tea, Omega 3 rich oily fish (salmon, sardines, mackerel etc), whole grains, nuts and olive oil.

How you can avoid Alzheimer's NutriShield Multi Vitamins and Minerals

Why these foods? Because oily fish (and some nuts and seeds like walnuts and flaxseeds) provide Omega 3 which is important for brain health and normal neuron connections. Berry fruits and leafy greens are high in flavonoids and polyphenols which are brain protective.

A study published in the Journal of the Alzheimer’s Association found that adults following a MIND diet had a 53% lower risk of developing dementia than those eating a typical Western diet.

They went further – those eating the most MIND diet servings (in the top third of nutritional intake) were assessed as 7.5 years younger in biological age. Not just healthier brains, but younger brains!

But what is it in the MIND Diet that produces these results? Flavonoids and polyphenols

Flavonoids and polyphenols are a class of nutrients found in fruits and vegetables that are arguably as important for health as vitamins and minerals.

Flavonoids include the colourants in the skins of plants – powerful nutrients like the carotenoids, beta carotene, lycopene and lutein. Carotenoids help prevent the formation of the beta amyloid plaques and tangles that degrade neuron brain cells and characterise an Alzheimer’s brain. [They are also important anti-cancer nutrients.]

How you can avoid Alzheimer's NutriShield Multi Vitamins and Minerals

But flavonoids have another property. They have both an antioxidant and anti-inflammatory effect.

The brain is a fatty organ – and researchers have shown that oxidation or free radical damage to fats sheathing neurons in the brain is a contributory cause of dementia. Anti-oxidants counteract this oxidation and help prevent and slow that damage.

Inflammation in the brain is another contributory cause. So anti-inflammatory nutrients like flavonoids can help prevent inflammation damage.

The effect is not just to keep the brain healthy – the high antioxidant levels in the MIND diet help reduce free radical damage to DNA, tissues and cells throughout the body, which otherwise can lead to cancer.

Furthermore, the MIND diet is also a natural immune system booster. It’s high in vitamins and minerals like vitamin A, C and D, zinc, in flavonoids, carotenoids and in Omega 3 – all of which strongly support the immune system.

Finally, the MIND diet improves blood sugar levels and therefore helps protect against diabetes, which in turn lowers the risk of dementia.

Omega 3 is vital for brain health

Sometime between 195,000 and 125,000 years ago, humans nearly went extinct. An ice age set in and much of the earth was ice covered and uninhabitable. The population of our hominid ancestors may have crashed to as little as a few thousand – and most anthropologists agree that everyone alive today is descended from this small group.

The archaeological evidence is that this group almost certainly survived by extending their hunting and gathering to the coastal areas of Africa.

How you can avoid Alzheimer's NutriShield Multi Vitamins and Minerals

There they were able to harvest shellfish and cold-water fish which are rich in Omega 3 fatty acids. These fats, it is believed, helped drive the evolution of our highly complex brains – which are over 60% poly-unsaturated fat in composition.

Within Omega 3 is a compound called DHA. DHA is possibly the single most important nutrient for brain health. It facilitates the communication between brain cells and is critical to the growth and survival of healthy brain cells. It also helps reduce inflammation in the brain and in other body tissues.

In study after study, diets rich in Omega 3 are found to be protective of brain health. These include the Mediterranean diet, the Japanese Okinawan diet and certain Scandinavian diets.

Keep body and brain active to reduce risk too

The hippocampus is a part of the brain that is critical to memory. Normally it shrinks by 1 to 2 percent a year as you get older, leading to potential cognitive impairment, a prelude to dementia. But research shows that that just 40 minutes of brisk walking, three times per week, leads to significant brain growth.

In one study, adults who participated in aerobic exercise – the level where you breathe harder – saw an over 2% INcrease in the size of their hippocampus over one year, in contrast to a 1.4% decline in control subjects.

That’s because exercise raises levels of a brain chemical called BDNF that encourages the growth of new brain cells.

A University of California study shows that people who are regularly physically active have far fewer of the plaques and tangles that are characteristic of Alzheimer’s.

How you can avoid Alzheimer's NutriShield Multi Vitamins and Minerals

Finally, avoid sitting too long without a break. Taking a short break every hour and stretching for even a minute or two can make a significant difference to long-term brain and general health.

To physical activity add some mental effort, whether crosswords, sudoku, or learning something new like a musical instrument or language. Use it or lose it!

If your activities are done with others so much the better, because research shows loneliness can impair cognitive health.

Brush your teeth

Recent research, reported in 2019 in Science Advances and posted on the UK National Health Service site, has linked gum disease to Alzheimer’s.

How you can avoid Alzheimer's NutriShield Multi Vitamins and Minerals

The researchers have noted that bacteria called P. gingivalis, which cause gingivitis, are significantly more common in people with Alzheimer’s than in people without – almost doubly more common. And the harmful proteins produced by P. gingivalis are present in higher concentrations in the brains of Alzheimer’s sufferers.

When mice were infected by the bacterium, they began to show increased tau protein and tangles, which are characteristic of the mental deterioration of people with early stage dementia.

The research has even triggered false internet claims that “you can catch Alzheimer’s”!

But a closer reading of the research shows that this is a small a scale study, involving lab tests on brain tissue and on mice. These types of study are both useful and necessary as early studies, but not necessarily conclusive. And a link between gum disease and Alzheimer’s doesn’t necessarily mean it causes Alzheimer’s. Correlation is not causation!

What is true, however, is that inflammation in the brain is definitely present in Alzheimer’s patients and gingivitis is an inflammatory disease – all diseases ending in ‘-itis’ are.

At this stage, the safe conclusion is to reduce pro-inflammatory foods in your diet and increase your intake of anti-inflammatory foods and supplements.

Improving on the MIND Diet

Add CURCUMIN/TURMERI

Recent research shows that curcumin (the active ingredient in turmeric) may help prevent the accumulation of plaques that build up in the brains of Alzheimer’s patients – and which interfere with communication between brain cells. Indeed, curcumin activates hundreds of genes that are anti-inflammatory and neuro (brain) protective.

How you can avoid Alzheimer's NutriShield Multi Vitamins and Minerals

Add BETAINE

There is also recent evidence, published in 2019 in the European Journal of Pharmacology, that a nutrient called betaine could have an important preventative role to play.

The researchers state: “betaine is the first potential medicine that can act preventively, instead of just easing the symptoms”. 

It’s important to qualify that this very recent study was on mice and needs to be confirmed in humans – but the report does state that betaine “significantly improves memory and oxidative stress in mice, which indicates that a new AD (Alzheimer’s Disease) medicine might have been found”.

Since we know that betaine also lowers heart disease risk, it is certainly worth including betaine rich foods in your diet (like seafood and wheatgerm) and betaine should be included in a health supplement that aims for brain health.

Add MULTI-STRAIN PROBIOTICS

Probiotics – ‘good’ bacteria – might improve brain function in existing Alzheimer’s patients.  A 2016 study published in Frontiers in Aging Neuroscience reported on 60 Alzheimer’s patients who drank milk that included four probiotic bacteria species for 12 weeks.

The strains were Lactobacillus acidophilus, Lactobacillus casei, Bifidobacterium bifidum, and Lactobacillus fermentum.

There was a ‘statistically significant’ improvement of cognitive function compared with those who drank regular milk.

How you can avoid Alzheimer's NutriShield Multi Vitamins and Minerals

Although researchers do not yet know exactly how gut bacteria influence behaviour or brain function, one theory is that a leaky gut may allow compounds to pass into the blood stream that harm the brain.

By reducing the permeability of the intestinal walls, certain probiotics like Lactobacillus and Bifidobacterium may help prevent this leakage.

It might, therefore, be worth considering a multi-strain probiotic as part of an overall programme to cut the risk of Alzheimer’s.

A Best of the Best Eating Plan

At the end of this article is an eating plan that improves even on the MIND Diet, in that it includes curcumin, betaine and other specifically neuro-protective foods and nutrients.

BUT if you’re trying to get all the nutrients you need by eating only regular food, you may find it difficult. For instance, the number of daily portions of fruits and vegetables in the MIND studies is considerably higher than a simple 5-a-day recommendation.

Indeed, both the American Cancer Society and University College London in a recent huge study conclude that the ideal intake is 9-10 portions of fruits and vegetables a day – plus 2-3 portions of oily fish a week.

At these levels your intake of vitamins, minerals and flavonoids ensures that your blood chemistry becomes seriously protective against age-related illness generally, and dementia in particular.

How you can avoid Alzheimer's NutriShield Multi Vitamins and Minerals

For most people 70 portions of fruit and veg a week is not achievable. Consequently, I believe that people over the age of 50 – who do not generally absorb nutrients as well as younger people – should take a supplement.

That supplement should include flavonoids, which are as important to health as vitamins and minerals. It should also include curcumin, betaine, Omega 3, and the nutrients that promote positive gene expression – like lutein, lycopene, beta carotene, extra B vitamins and vitamin D.

A simple one-a day multivitamin just isn’t enough.

Modified MIND Diet plus NutriShield health supplement

The one-page summary of the ideal, enhanced MIND diet therefore includes a health supplement called NutriShield Premium, which supplies all these extra nutrients. It was originally designed by Dr Paul Clayton, former Chair of the Forum on Food and Health at the Royal Society of Medicine. And – full disclosure – it is a supplement we created in response to the research on healthy ageing and brain health.

How you can avoid Alzheimer's NutriShield Multi Vitamins and Minerals

Unlike most supplements, NutriShield doesn’t just contain the basic RDA (Recommended Daily Allowance) amounts of vitamins and minerals, which only prevent outright deficiencies. Instead, it’s designed to provide you daily with the wide range and high level of nutrients found in the very healthiest diets.

You can download the plan free here.

How you can avoid Alzheimer's NutriShield Multi Vitamins and Minerals

How you can avoid Alzheimer's NutriShield Multi Vitamins and Minerals

This article was written by Colin Rose, a Senior Associate Member of the Royal Society of Medicine, who has been writing on science for 40 years.


If you found this article helpful and believe it can help others who are concerned to help prevent dementia, then please share it. You can also follow me through the icons below.

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How you can avoid Alzheimer's NutriShield Multi Vitamins and Minerals
Register now for a free monthly e-newsletter on the latest in nutrition and health research.


How you can avoid Alzheimer's NutriShield Multi Vitamins and Minerals

Dr Paul Clayton designed NutriShield as a comprehensive health supplement with OPTIMUM levels of essential nutrients. See more detail elsewhere on this site or click on the button.


How you can avoid Alzheimer's NutriShield Multi Vitamins and Minerals

Dr Paul Clayton’s best-selling book Health Defence is available from booksellers.

Read it here online or see the website www.healthdefence.com for excerpts and links to buy direct from the publisher.


How you can avoid Alzheimer's NutriShield Multi Vitamins and Minerals

See online here for delicious recipes from the Health Defence Cookbook incorporating healthy foods featuring in a Mediterranean Diet.


References:

MIND diet associated with reduced incidence of Alzheimer’s disease; Morris MC et al, Alzheimers Dement. 2015 Sep;11(9):1007-14.

Involvement of GAT2/BGT-1 in the preventive effects of betaine on cognitive impairment and brain oxidative stress in amyloid β peptide-injected mice. Ibi, D, Tsuchihashi A, Nomura T & Hiramatsu M. (2019). European Journal of Pharmacology842, 57-63.

Exercise training increases size of hippocampus and improves memory. Sayal N (2015) Annals of Neurosciences, 22(2). doi:10.5214/ans.0972.7531.22

Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. Gomes AP et al, Cell. 2013 Dec 19;155(7):1624-38. doi: 10.1016/j.cell.2013.11.037.

Betaine in human nutrition; Stuart AS Craig The American Journal of Clinical Nutrition, Volume 80, Issue 3, November 2004, Pages 539–549

Nutrition and the Risk of Alzheimer’s Disease; Nan Hu et al; Biomed Res Int. 2013: 524820.

Link: ghr.nlm.nih.gov/gene/BDNF

Porphyromonas gingivalis in Alzheimer’s Disease brains: Evidence for disease causation and treatment with small-molecule inhibitors; Stephen S. Dominy et al; Science Advances, 23 Jan 2019: Vol. 5, no. 1, eaau3333


B vitamins stop pre-Alzheimer’s brain shrinkage

B vitamin complex halts brain shrinkage that precedes Alzheimer’s

B vitamins stop pre-Alzheimer's brain shrinkage NutriShield Multi Vitamins and Minerals

If you or any family member is at risk of Alzheimer’s, a new study by Oxford, Warwick and Oslo universities brings hope.

Alzheimer’s and dementia are possibly the most feared ‘age-related’ diseases today. They rob sufferers of memories and so much that makes a normal life enjoyable. Worryingly, dementia is now the leading cause of death for women in England and Wales.

Unfortunately, good news on Alzheimer’s from conventional medical sources is hard to come by – because most drug research has hit a brick wall. There is no conventional cure.

But this recent study shows that an inexpensive nutrient combination may help where costly drugs have failed.

Warning signs of Alzheimer’s

One of the warning signs of Alzheimer’s is a shrinkage in brain ‘grey matter’ which can begin as much as 10 years before the characteristic sticky amyloid plaques and tangles begin to show up on MRI scans. ‘Grey matter’ is a complex of brain nerve cells in areas of the brain responsible for memory and reasoning. In people with Alzheimer’s, areas of grey matter shrink and shrivel.

B vitamins stop pre-Alzheimer's brain shrinkage NutriShield Multi Vitamins and Minerals

B vitamins reduce homocysteine risk factor

The university researchers already knew that vitamins B12, B6 and folic acid reduce blood levels of an amino acid called homocysteine. A 2002 study published in the New England Journal of Medicine had confirmed that people with high blood levels of homocysteine had a significantly greater risk of developing Alzheimer’s Disease.

Indeed, a high level of homocysteine is a predictor not just of Alzheimer’s, but of heart disease and stroke. It’s an all-round disease risk factor.

Clinical trial of B vitamins

The researchers conducted a randomised controlled trial on two groups of patients who had already been diagnosed with mild cognitive impairment – the type that frequently leads to the much more devastating Alzheimer’s.

One group received 0.5mg of Vitamin B12 a day, 20mg of B6 and 800mcg of Folic Acid; the second group received a placebo.

A huge positive effect on the brain

Patients had a brain scan at the start of the trial and again after two years.

In the group receiving the B complex, and who had above average homocysteine levels, the reduction in brain shrinkage was almost 85%!

Lead researcher David Smith stated:

“It’s a big effect – much bigger than we would have dreamed of … It’s the first and only disease-modifying treatment that’s worked.”

Paul Thompson, professor of Neurology at UCLA School of Medicine, commented:

“I have never seen results from brain scans showing this level of protection.”

Reducing homocysteine decreased the rate of grey matter loss

The sequence observed in the trial was that reducing homocysteine levels led to a big decrease in the rate of grey matter loss and a corresponding limit on cognitive decline.

But when quizzed, the researchers could not say that B complex supplementation prevented Alzheimer’s – only that it reduced the shrinkage of grey matter that usually precedes Alzheimer’s and dementia.

More evidence from the 100,000-person “Whitehall” cohort study

But other evidence allows us to make a more definite conclusion. The Whitehall 11 Cohort Study on over 100,000 people with an average age of around 55 clearly shows that those at the most risk of heart disease and stroke are also at the most risk of dementia.

Because elevated homocysteine levels are not only damaging to brain health – they are damaging to vascular health, and are linked to blood clots, stroke and heart attacks.

Indeed we know that some 50% of people who have a heart attack have normal cholesterol levels – but many of them have high homocysteine levels.

Three killer diseases – Alzheimer’s, heart attacks and strokes – have three recognised common denominators:

  1. Elevated homocysteine levels
  2. Chronic inflammation
  3. Reduced blood flow because of constricted blood vessels

So an overall strategy to reduce the risk of dementia would address these three – interlinked – threats.

More non-drug ways to reduce homocysteine and cut disease risk

Although homocysteine levels in the blood often increase simply with age, they also increase with the use of alcohol, the anxiety medication benzodiazepines, obesity, inactivity and a genetic mutation called MTHFRC677T.

So increasing your activity levels every day and keeping to a healthy weight are other proven ways to reduce the risk of dementia.

B vitamins stop pre-Alzheimer's brain shrinkage NutriShield Multi Vitamins and Minerals

Reducing inflammation

There is a huge body of research to show that internal inflammation that builds up in tissues – including brain tissues – is a or possibly even the, driver, not just of dementia, but heart disease, stroke, diabetes and some cancers. And ageing itself.

Dr Brian Giunta, a neuroscientist at the University of Southern Florida, explains that cells in the brain called microglia can become constantly inflamed – and less able to clear beta amyloid proteins from the brain. This beta amyloid then kills neurons – leading to Alzheimer’s.

The main way to reduce inflammation is to increase your intake of plant-based foods and oily fish.

B vitamins stop pre-Alzheimer's brain shrinkage NutriShield Multi Vitamins and Minerals

Exciting easy recipes to help you eat more anti-inflammatory foods online here

In terms of supplements, the following all help damp down inflammation:  Omega 3 and plant micro-nutrients like curcumin, green tea extract, grapeseed extract, soy isoflavones, lutein and lycopene.

There is a full report on reducing inflammation called Inflamm-Ageing at http://www.inflamm-ageing.com/

Increasing blood flow

What’s bad for the heart is bad for the brain. Restricted blood flow to the heart is, of course, a main cause of heart disease – and it is also a major factor in both vascular dementia and Alzheimer’s.

In vascular dementia, the brain doesn’t receive enough blood, and therefore enough oxygen, which results in nerve cell death. Blood flow to the brain is also reduced in patients with Alzheimer’s Disease and this may be another reason that neurons die in this form of dementia, too.

Some clinicians have even termed vascular dementia as ‘atherosclerosis of the brain’. So the same strategies for increasing blood flow and reducing blood pressure apply to preventing vascular dementia as well as heart disease and stroke.

A comprehensive anti-Alzheimer’s health regime

Strategies include increased physical activity, increased fruit and vegetable intake and an anti-oxidant-rich supplement that includes Omega 3, curcumin, co-enzyme Q10, and the plant micro-nutrients lutein, lycopene, green tea and grapeseed flavonoids and soy isoflavones.

All these anti-inflammatory and anti-oxidant nutrients – plus high levels of B complex – are in the health supplement called NutriShield, designed by Dr Paul Clayton, former Chair of the Forum on Food and Health at the Royal Society of Medicine. Its objective is to reduce inflammation, reduce homocysteine levels, increase normal blood flow and provide the building blocks for health cell renewal and DNA repair.

As Hilary Evans of Alzheimer’s Research UK says:

“Dementia is not an inevitable part of ageing; it’s caused by diseases that can be fought through research, and we must bring all our efforts to bear on what is now our greatest medical challenge.”

 


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B vitamins stop pre-Alzheimer's brain shrinkage NutriShield Multi Vitamins and Minerals And register now for a free regular e-newsletter on the latest in nutrition and health research.


Dr Paul Clayton designed NutriShield as a comprehensive healthB vitamins stop pre-Alzheimer's brain shrinkage NutriShield Multi Vitamins and Minerals supplement with OPTIMUM levels of essential nutrients including polyphenols and flavonoids from fruits, vegetables and other plants. See more detail elsewhere on this site or click on the button.


B vitamins stop pre-Alzheimer's brain shrinkage NutriShield Multi Vitamins and MineralsDr Paul Clayton’s best-selling book Health Defence is available from bookstores or from Uni-Vite Healthcare here.

A free summary report and the opportunity to read the book online is available here.


See online here for delicious recipes from the Health Defence Cookbook  incorporating healthy foods featuring in a Mediterranean Diet. B vitamins stop pre-Alzheimer's brain shrinkage NutriShield Multi Vitamins and Minerals


REFERENCES

Preventing Alzheimer’s disease-related grey matter atrophy by B-vitamin treatment. Douaud G, Refsum H, de Jager CA, Jacoby R, Nichols TE, Smith SM, Smith AD. Proc Natl Acad Sci USA. 2013 Jun 4;110(23):9523-8. doi: 10.1073/pnas.1301816110.

Physical activity and cognitive function in individuals over 60 years of age: a systematic review; Ashley Carvalho. Clin Interv Aging. 2014; 9: 661–682. Published online 2014 Apr 12. doi:  10.2147/CIA.S55520

https://www.alzdiscovery.org/news-room/blog/inflammation-the-driver-of-alzheimers-disease