Inflammation demands anti-anflammatory vitamins and minerals

Dr Paul Clayton 2013

Internal inflammation – the health danger that threatens us all

Health researchers now believe they have identified a, or probably even THE, key reason why health seems to inevitably decline with age, and why we therefore need anti-inflammatory supplements to counter it. It’s called ‘chronic, sub-clinical inflammation.’

“Inflammation is an underlying contributor to virtually every chronic disease … rheumatoid arthritis, Crohn’s disease, diabetes and depression, along with major killers such as heart disease and stroke.

“The connection between inflammation and cancer has now moved to center stage in the research arena.” Scientific American

“Low-grade inflammation is associated with everything from heart disease and diabetes to Alzheimer’s and arthritis, and may even be the cause of most chronic diseases.”
University of California Berkeley, School of Public Health

“Inflammatory processes … are likely to be involved in coronary heart disease.”
British Medical Journal

“Inflammatory factors predict virtually all bad outcomes in humans … having heart attacks, having heart failure, becoming diabetic … becoming fragile in old age … cognitive function decline, even cancer to a certain extent.”
Russell Tracy, Professor of Pathology and Biochemistry, University of Vermont College of Medicine

This type of inflammation is labelled chronic because it is a low level of continuous, ‘grumbling’, inflammation that over the years causes more and more damage to tissues in the arteries, brain, and joints until eventually it becomes manifest as an ‘age-related’ disease.

Except that ageing doesn’t cause chronic inflammation – it’s the other way around. Chronic inflammation causes ageing.

Inflammation demands anti-anflammatory vitamins and minerals NutriShield Multi Vitamins and Minerals

The other part of the description – sub-clinical – comes from its internal and largely undetectable nature, making it all the more dangerous.

The fact that it is internal is also the reason why, until recently, we have been unaware of the research and its huge significance to health. For most of us, inflammation is the body’s helpful external response to a cut or insect bite.

Internal inflammation damages tissues over the long term. And that’s bad news.

The good news is that you can take effective action against this type of inflammation and all the evidence is that this will then reduce the risk of the health issues that threaten us as we age.

Anti-inflammatory vitamins, minerals and other nutrients
The main priority is to increase the level of anti-inflammatory foods and nutrients in your diet.

See: Natural anti-inflammatory nutrients

They key elements here are the polyphenols and flavonoids in many fruits and vegetables and Omega 3 fish oil – all of which are powerful anti-inflammatories.

That’s why there is overwhelming evidence that Omega 3 fish oil is heart-protective, helps to protect brain function and has a role to play in reducing the risk of cancer. But few people have sufficient Omega 3 in their normal diet. You would need to eat 3-4 portions of oily fish such as herring, mackerel, sardines or wild salmon (not farmed) a week!

There is equally good evidence to support the importance of polyphenol anti-inflammatories to our long-term health. So much so that the American Cancer Society and many other authorities now recommend nine portions of fruit and vegetables a day!

Can you get enough anti-inflammatory vitamins and minerals from foods alone?
For many, these recommendations are difficult to achieve, which is why many health scientists like myself are positive on the role of a well-designed supplement that adds anti-inflammatory nutrients like Omega 3 and flavonoids and polyphenols like green tea extract, curcumin and grapeseed extract to a full range of vitamins and minerals.

DOWNLOAD my free e-book Inflamm-ageing now HERE.

1. Clayton P, Rowbotham J. How the mid-Victorians worked, ate and died. Int J Environ Res Public Health. 2009 Mar;6(3):1235-53
2. Ames BN. Low micronutrient intake may accelerate the degenerative diseases of aging through allocation of scarce micronutrients by triage. Proc Natl Acad Sci U S A. 2006 Nov 21;103(47):17589-94
3. Ames BN. Optimal micronutrients delay mitochondrial decay and age-associated diseases. Mech Ageing Dev. 2010 Apr 24. [Epub ahead of print]
4. Schick B. A tea prepared from needles of pine trees against scurvy. Science. 1943 Sep 10;98(2541):241-2
5. Bolland MJ, Avenell A, Baron JA, Grey A, Maclennan GS, Gamble GD, Reid IR. Effect of calcium supplements on risk of myocardial infarction and cardiovascular events: meta-analysis. BMJ. 2010 Jul 29;341:c3691. doi: 10.1136/bmj.c3691.
6. IoM Worksop Summary. The Development of DRIs 1994–2004: Lessons Learned and New Challenges. November 30, 2007
7. Jiang Q, Moreland M, Ames BN, Yin X. A combination of aspirin and gamma-tocopherol is superior to that of aspirin and alpha-tocopherol in anti-inflammatory action and attenuation of aspirin-induced adverse effects. J Nutr Biochem. 2009 Nov;20(11):894-900
8. Royer MC, Lemaire-Ewing S, Desrumaux C, Monier S, Pais de Barros JP, Athias A, Néel D, Lagrost L. 7-ketocholesterol incorporation into sphingolipid/cholesterol-enriched (lipid raft) domains is impaired by vitamin E: a specific role for alpha-tocopherol with consequences on cell death. J Biol Chem. 2009 Jun 5;284(23):15826-34
9. Sacha B, Zierler S, Lehnardt S, Weber JR, Kerschbaum HH. Heterogeneous effects of distinct tocopherol analogues on NO release, cell volume, and cell death in microglial cells. J Neurosci Res. 2008 Dec;86(16):3526-35
10. Ren Z, Pae M, Dao MC, Smith D, Meydani SN, Wu D. Dietary supplementation with tocotrienols enhances immune function in C57BL/6 mice. J Nutr. 2010 Jul;140(7):1335-41
11. Sen CK, Khanna S, Roy S. Tocotrienols in health and disease: the other half of the natural vitamin E family. Mol Aspects Med. 2007 Oct-Dec;28(5-6):692-728. Epub 2007 Mar 27. Review.
12. Comitato R, Leoni G, Canali R, Ambra R, Nesaretnam K, Virgili F. Tocotrienols activity in MCF-7 breast cancer cells: involvement of ERbeta signal transduction. Mol Nutr Food Res. 2010 May;54(5):669-7
13. Pierpaoli E, Viola V, Pilolli F, Piroddi M, Galli F, Provinciali M. Gamma- and delta-tocotrienols exert a more potent anticancer effect than alpha-tocopheryl succinate on breast cancer cell lines irrespective of HER-2/neu expression. Life Sci. 2010 Apr 24;86(17-18):668-75
14. Grant WB, Schwalfenberg GK, Genuis SJ, Whiting SJ. An estimate of the economic burden and premature deaths due to vitamin D deficiency in Canada. Molecular Nutrition & Food Research 2010 March 29th.Published online ahead of print, doi: 10.1002/mnfr.200900420
15. Hanley DA, Cranney A, Jones G, Whiting SJ, Leslie WD, Cole DE, Atkinson SA, Josse RG, Feldman S, Kline GA, Rosen C. Vitamin D in adult health and disease: a review and guideline statement from Osteoporosis Canada. CMAJ. 2010 Jul 19
16. “Dietary Supplement Fact Sheet: Vitamin D” Retrieved 2010-03-25
17. Vieth R. Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety. Am J Clin Nutr. 1999; 69(5):842-56.
18. Vieth R, Chan P-C, MacFarlane GD: Efficacy and safety of vitamin D3 intake exceeding the lowest observed adverse effect level. Am J Clin Nutr 2001;73:288–94.
19. Adams JS, Clemens TL, Parrish JA, Holick MF Vitamin-D synthesis and metabolism after ultraviolet irradiation of normal and vitamin-D-deficient subjects. N Engl J Med.1982 Mar 25;306(12):722-5
20. Munro I, Derivation of tolerable upper intake levels of nutrients, Letter, Am J Clin Nutr 2001; 74:865
21. Woodhead JS, Ghose RR, Gupta SK. Severe hypophosphataemic osteomalacia with primary hyperparathyroidism. Br Med J 1980; 281:647-648.
22. Eguchi M, Kaibara N. Treatment of hypophosphataemic vitamin D-resistant rickets and adult presenting hypophosphataemic vitamin D-resistant osteomalacia. Int Orthop 1980; 3:257-264.
23. Schurgers LJ, Vermeer C. Differential lipoprotein transport pathways of K-vitamins in healthy subjects. Biochim Biophys Acta. Feb 15 2002;1570(1):27-32.
24. Schurgers LJ, Cranenburg EC, Vermeer C. Matrix Gla-protein: the calcification inhibitor in need of vitamin K. Thromb Haemost. 2008 Oct;100(4):593-603. Review.
25. Knapen MH, Schurgers LJ, Vermeer C. Vitamin K2 supplementation improves hip bone geometry and bone strength indices in postmenopausal women. Osteoporos Int. 2007 Jul;18(7):963-72
26. Kim KH, Choi WS, Lee JH, Lee H, Yang DH, Chae SC. Relationship between dietary vitamin K intake and the stability of anticoagulation effect in patients taking long-term warfarin. Thromb Haemost. 2010 Jul 20;104(4)
27. Kaneki M, Hodges SJ, Hosoi T, Fujiwara S, Lyons A, Crean SJ, Ishida N, Nakagawa M, Takechi M, Sano Y, Mizuno Y, Hoshino S, Miyao M, Inoue S, Horiki K, Shiraki M, Ouchi Y, Orimo H. Japanese fermented soybean food as the major determinant of the large geographic difference in circulating levels of vitamin K2: possible implications for hip-fracture risk. Nutrition. 2001 Apr;17(4):315-21
28. Bolland MJ, Grey A, Avenell A, Gamble GD, Reid IR. Calcium supplements with or without vitamin D and risk of cardiovascular events: reanalysis of the Women’s Health Initiative limited access dataset and meta-analysis. BMJ 2011 Apr 19;342:d2040.
29. Krebs-Smith SM, Guenther PM, Subar AF, Kirkpatrick SI, Dodd KW. Americans do not meet federal dietary recommendations. J Nutr. 2010 Oct;140(10):1832-8.
30. Troesch B, Hoeft B, McBurney M, Eggersdorfer M, Weber P. Dietary surveys indicate vitamin intakes below recommendations are common in representative Western countries. Br J Nutr. 2012 Aug;108(4):692-8.
31. Fulgoni VL 3rd, Keast DR, Bailey RL, Dwyer J. Foods, fortificants, and supplements: Where do Americans get their nutrients? J Nutr. 2011 Oct;141(10):1847-54