Soy anti-cancer, good for menopause, heart and bone health

Soy anti-cancer, good for menopause, heart and bone health NutriShield Multi Vitamins and Minerals


DEFINITIVE GUIDE TO SOY AT A GLANCE

♦ SOY and its isoflavones are linked to lower breast cancer risk
♦ SOY and its isoflavones can reduce negative symptoms experienced during the menopause and help alleviate PMS symptoms for younger women
♦ SOY and its isoflavones can help lower blood pressure and improve heart health
♦ SOY and its isoflavones can contribute to stronger bones
♦ SOY and its isoflavones do NOT adversely affect male sex hormones – and may reduce prostate cancer risk


Cancer risk reduction for men and women

About 1 in 11 British women will develop breast cancer at some time in their lives. In Japan, the figure is as low as 1 in 65.

Epidemiologists – scientists who study outcome patterns in populations – believe that soy may play a crucial protective role against cancer.

The Japanese diet contains considerably more soy products than the typical Western one does, and that’s thought to protect against breast cancer – and indeed other cancers.

Soy beans are extremely rich in isoflavones, and these seem to be among the most potent anti-carcinogens of all.

Isoflavones block oestrogen, a hormone linked to an increased risk of breast and other hormone-dependent cancers. They act rather like Tamoxifen, a drug widely used to treat and prevent breast cancer.

Men who think that soy is just for women should think again; considering the high rate of prostate cancer in the West, it seems that men have just as much to gain from adding soy to their diet. And soy isoflavones do NOT adversely affect male hormones like testosterone – see below.

Soy isoflavones can help in the menopause

Soy anti-cancer, good for menopause, heart and bone health NutriShield Multi Vitamins and MineralsIsoflavones can also mimic the effect of oestrogen in the body. Research shows that they can significantly alleviate the negative symptoms that many women go through during the menopause.

Two of the most distressing symptoms during the menopause are hot flushes [in the US, called “hot flashes”] during the day and night sweats during bedtime. They are caused because, as oestrogen levels fall, what’s called ‘vasomotor function’ deteriorates.

Blood vessels on the surface of the skin normally dilate when we are hot – allowing hot blood to move to the surface and the heat to escape. But this ‘vasomotor’ sequence is affected by the hormonal changes at menopause, causing the surface blood vessels to dilate randomly and the skin to become hot and sweaty.

It’s known that Japanese women on average suffer fewer menopausal symptoms than Western women – and they consume far more soy.  Indeed, the average Japanese intake of soy isoflavones is at least 15mg a day, compared with 1mg average in the West.

After earlier conflicting evidence that soy could ease menopausal symptoms, a 2012 meta-analysis (a literature survey of existing clinical trials) confirmed that:

Consumption of 30mg/day of soy isoflavones … reduces hot flashes by up to 50%.”

Isoflavones are phytoestrogens

The key isoflavone nutrients in soy isoflavones are genistein and daidzein. These are found in soy beans, and to a lesser extent in chick peas and lentils, and they appear to be the most potent of the phytoestrogens.

It should be noted that the oestrogen potency of phytoestrogens is estimated to be less than 1% of oestradiol, the natural oestrogen, and this probably explains why earlier studies did not clearly show isoflavones to be effective in ameliorating the menopausal symptoms. After all, hormone levels vary significantly from woman to woman.

However, a recent (2017) study in the Journal of Clinical and Diagnostic Research once again confirmed that:

“Soy isoflavone improves the MRS score (a measurement of menopause symptoms) among both the perimenopausal (women transitioning into menopause) and postmenopausal women.”

A fair conclusion is that women who do not want to take hormone (replacement) therapy (HT or HRT) with oestrogen, and certainly women who have had breast cancer, should consider a supplement that includes soy isoflavones for relief of menopausal symptoms.

When NICE (the National Institute for Health and Care Excellence), published guidelines in 2015 for the menopause, they confirmed there is evidence that isoflavones may relieve vasomotor symptoms.

Soy isoflavones can help with PMS

Soy anti-cancer, good for menopause, heart and bone health NutriShield Multi Vitamins and MineralsSo far, we have concentrated on the benefits of soy isoflavones for older women. But new research has highlighted the fact that soy isoflavones – in soy or a supplement – can reduce PMS symptoms.

The National Association for Premenstrual Syndrome now states:

“Our data on this is limited; however, women in Asia, who have high levels of phytoestrogens in their diet, do have fewer PMS symptoms.”

They also recommend a diet that’s high in Omega 3, B complex, vitamin D, magnesium and calcium to help relieve PMS symptoms.

Soy isoflavones for heart health

Soy anti-cancer, good for menopause, heart and bone health NutriShield Multi Vitamins and MineralsLack of oestrogen after the menopause means that a woman’s risk of heart disease becomes comparable to a man’s. So it is logical that the plant oestrogens in soy isoflavones could be part of a heart health regime – for both women and men.

An article in Current Nutrition & Food Science confirmed that soy isoflavones were helpful in reducing blood pressure (see below), but that their effects were even stronger in preventing what doctors call ‘endothelial dysfunction’.

Preventing endothelial dysfunction

The endothelium is the thin lining on the inside of your blood vessels and arteries. It’s a vital part of the regular restriction and dilation that occurs over 60 times a minute as the heart beats. And all taking place within the almost 90,000 miles (!) of blood vessels that make up the arteries, veins and capillaries in the body.

The endothelium needs to be flexible and smooth to achieve healthy blood pressure and flow. In endothelial dysfunction, oxidation (free radical damage) causes lesions in this lining; LDL cholesterol sticks to these lesions and causes atherosclerosis – a build-up of fats that can then semi-calcify, all resulting in a narrowing and hardening of the arteries.

The result is atherosclerosis, hypertension and heart disease.

Isoflavones not only act as anti-oxidants to counteract excess free radical damage – they also reduce inflammation and help restore smoothness in the endothelium. A study in the European Heart Journal showed that as little as 12 weeks of isoflavone supplementation ‘reversed endothelial dysfunction’. The report concluded that:

“These findings may have important implications for the use of isoflavone for secondary prevention in patients with cardiovascular disease, on top of conventional interventions.”

Another meta-analysis of over 20 studies in Cardio-Vascular Discoveries Journal confirmed that isoflavones improved heart health, concluding that:

“Soy isoflavones had an effect of lowering blood pressure in hypertensive subjects.”

Soy isoflavones for bone health

Soy anti-cancer, good for menopause, heart and bone health NutriShield Multi Vitamins and MineralsLack of oestrogen also predisposes a woman to osteoporosis (bone loss). Indeed, osteoporosis means ‘porous bones’. So it’s logical that a isoflavone supplement might help preserve bone density in older women. Asian women, who consume far more soy than Western women, rarely suffer from osteoporosis after the menopause.

However, a well-conducted study reported in the American Journal of Clinical Nutrition found no difference in bone density after isoflavone supplementation. But it did find that increased protein intake improves bone density.

In a way that’s not surprising, because bone density is a function of much more than oestrogen. It needs adequate calcium, vitamins A and D that support the absorption of calcium, and minerals like magnesium and zinc, plus vitamin K, which are all needed to mineralise bone.

Soy isoflavones and breast cancer

Soy anti-cancer, good for menopause, heart and bone health NutriShield Multi Vitamins and MineralsPopulation studies show that eating a high-soy diet is linked to a slightly reduced risk of developing breast cancer.

As we have seen, Asian women with a traditional diet high in soy, appear to be less likely to develop breast cancer. This benefit continues even when Asian women move to western cultures, where soy is less likely to be a regular part of the diet. This suggests that exposure to soy early in life provides the most protection against breast cancer.

When small amounts of soy are fed to animals, their rate of breast cancer falls by nearly 50%, as does the incidence of prostate cancer.

A survey in the specialist journal Anti-Cancer Agents in Medicinal Chemistry confirmed these population observations concluding that:

“The majority of breast cancer cases are hormone-receptor-positive; therefore, soy isoflavones should be considered a potential anti-cancer therapeutic agent.”

Genistein appears to be the key isoflavone. Whilst it has little effect on normal cells, it appears to be a powerful inhibitor of nearly every cancer cell type examined so far.

But genistein doesn’t just inhibit cancer cells. In vitro it can cause cancer cells to revert to normal cells – which is an absolutely crucial anti-cancer property, called ‘re-differentiation’.

Genistein seems to have yet another another amazing property. It inhibits the growth of new blood vessels, and may therefore be able to starve cancers even after they have begun to grow.

Other nutrients can work with soy to increase cancer protection. If you follow a modified Mediterranean Diet with a supplement that includes vitamin D, vitamin E, selenium, carotenoids like lutein and lycopene, Omega 3, betaine, green tea and grapeseed extract, you will have the basis of a strong, evidence-based anti-cancer regime.

Soy isoflavones and men’s health – NO adverse effects

Soy anti-cancer, good for menopause, heart and bone health NutriShield Multi Vitamins and MineralsIf soy isoflavones act as oestrogen mimics, are they safe for men – and do they affect testosterone levels or sex drive?

A survey of 47 studies on that subject is quite clear – they don’t adversely affect men. The summary in Fertility Journal concluded:

“The results of this meta-analysis suggest that neither soy foods nor isoflavone supplements alter measures of bioavailable T (testosterone) concentrations in men”.

But why? First of all, men produce the hormone oestrogen too – albeit at lower levels than women.

Secondly, we have seen that the hormone effect of soy isoflavone phytoestrogens is almost 100 times less than that of oestradiol, the natural form of oestrogen.

Thirdly, Asian men who consume many times more isoflavones from soy than Western men, have no lower levels of fertility and sex drive.

In fact, the International Society of Sexual Medicine answers the question: “Does consuming soy affect a man’s testosterone level?” with the simple answer: ‘NO’.

There is some evidence, however, that taking isoflavones does increase a woman’s desire levels, as lower oestrogen is linked to vaginal dryness and lower libido.  A diet rich in B complex vitamins, vitamin E, with isoflavones (plus exercise and de-stressing) does seem to deliver a libido boost – especially during and after the menopause.

Soy isoflavones and prostate cancer

Soy anti-cancer, good for menopause, heart and bone health NutriShield Multi Vitamins and MineralsThe US National Library of Medicine published a summary of all the research on the impact of soy isoflavones on prostate cancer.

They found:

“a significant reduction in PCa (Prostate Cancer) diagnosis after administration of soy/soy isoflavones. There may be support for epidemiological findings of a potential role for soy/soy isoflavones in PCa risk reduction.”

Once again, men looking to achieve a significant reduction in the risk of prostate cancer would not rely on one ingredient like soy isoflavones.

But as we just advised for women, a Modified Mediterranean Diet with a supplement that also includes vitamin D, vitamin E, carotenoids like lutein and lycopene, Omega 3, betaine, green tea and grapeseed extract, provides the basis of a strong, evidence-based anti-cancer regime.

Soy supplements

Soy isoflavones on their own are not the only or ideal health protective nutrients. NutriShield Premium is a daily comprehensive supplement containing 43 nutrients including 40mg of soy isoflavones with 28.8mg of genistein, 9.6mg of daidzein and 1.6mg of glycitin, designed by Dr Paul Clayton, former Chair of the Forum on Food and Health at the Royal Society of Medicine.

Soy anti-cancer, good for menopause, heart and bone health NutriShield Multi Vitamins and Minerals

 


If you enjoyed this article, please share it with family and friends.

Soy anti-cancer, good for menopause, heart and bone health NutriShield Multi Vitamins and MineralsSoy anti-cancer, good for menopause, heart and bone health NutriShield Multi Vitamins and MineralsSoy anti-cancer, good for menopause, heart and bone health NutriShield Multi Vitamins and Minerals

You can follow us on Facebook or Twitter for daily headline health tweets.


Soy anti-cancer, good for menopause, heart and bone health NutriShield Multi Vitamins and Minerals And register now for a free regular e-newsletter on the latest in nutrition and health research.


Dr Paul Clayton designed NutriShield as a comprehensive healthSoy anti-cancer, good for menopause, heart and bone health NutriShield Multi Vitamins and Minerals supplement with OPTIMUM levels of 43 essential nutrients including soy isoflavones, polyphenols and flavonoids from fruits, vegetables and other plants, Omega 3, betaine and greent tea. See more detail elsewhere on this site or click on the button.


Soy anti-cancer, good for menopause, heart and bone health NutriShield Multi Vitamins and MineralsDr Paul Clayton’s best-selling book Health Defence is available from bookstores or from Uni-Vite Healthcare here.

A free summary report and the opportunity to read the book online is available here.


See online here for delicious recipes from the Health Defence Cookbook  incorporating healthy foods featuring in a Mediterranean Diet. Soy anti-cancer, good for menopause, heart and bone health NutriShield Multi Vitamins and Minerals


REFERENCES

Effect of soy isoflavones on blood pressure: a meta-analysis of randomized controlled trials. Liu XX, et al; Nutr Metab Cardiovasc Dis. 2012 Jun;22(6):463-70. doi: 10.1016/j.numecd.2010.09.006. Epub 2011 Feb 9.

Clinical studies show no effects of soy protein or isoflavones on reproductive hormones in men: results of a meta-analysis. Hamilton-Reeves JM, Vazquez G, Duval SJ, Phipps WR, Kurzer MS, Messina MJ. Fertil Steril.  2010 Aug;94(3):997-1007. doi: 10.1016/j.fertnstert.2009.04.038. Epub 2009 Jun 12

Soy and soy isoflavones in prostate cancer: a systematic review and meta-analysis of randomized controlled trials. van Die MD, Bone KM, Williams SG, Pirotta MV. BJU Int. 2014 May;113(5b):E119-30. doi: 10.1111/bju.12435.

Quantitative efficacy of soy isoflavones on menopausal hot flashes. Lujin Li, Yinghua Lv, Ling Xu, and Qingshan Zheng; Br J Clin Pharmacol. 2015 Apr; 79(4): 593–604.

The Effect of Soy Isoflavones on the Menopause Rating Scale Scoring in Perimenopausal and Postmenopausal Women: A Pilot Study. Marya Ahsan and Ayaz Khurram Mallick. J Clin Diagn Res. 2017 Sep; 11(9): FC13–FC16.

Endothelial Dysfunction: Cardiovascular Risk Factors, Therapy, and Outcome: Hadi AR Hadi, Vasc Health Risk Manag. 2005 Sep; 1(3): 183–198.

Soy and Its Isoflavones: The Truth Behind the Science in Breast Cancer:  Crystal C. Douglas et al;  Anti-Cancer Agents in Medicinal Chemistry; Volume 13 , Issue 8 , 2013

Soy proteins and isoflavones affect bone mineral density in older women: a randomized controlled trial. Anne M Kenny, et al; Am J Clin Nutr. 2009 Jul; 90(1): 234–242.

Potassium, magnesium, and fruit and vegetable intakes are associated with greater bone mineral density in elderly men and women.  Tucker KL, Hannan MT, Chen H, et al. (1999)  Am J Clin Nutr 69:727-736

 

 

Autism linked to vitamin D deficiency

Autism* linked to Vitamin D deficiency

*and other brain development issues

Autism linked to vitamin D deficiency NutriShield Multi Vitamins and Minerals

30 years ago the rate of autism was no more than 1 child in 2,500. Today it is 1 in 100 according to the UK National Autistic Society.

It may even be as high as 1 in 68 in the USA, according to the US Centers for Disease Control and Prevention.

That’s an astonishing 3,500% increase (using the US figures) in a generation, or 35 times more common.

Vitamin D deficiency in pregnancy a key factor

Although it is undoubtedly partly due to better diagnosis, researchers at the University of Queensland’s Brain Institute have identified vitamin D deficiency in pregnancy as a key factor.

The study, led by researcher Professor John McGrath, found that pregnant women with low vitamin D levels at 20 weeks’ gestation were 400% or 4 times more likely to have a child with autistic traits by the age of six.

“This study provides further evidence that low vitamin D is associated with neurodevelopmental disorders,” said Professor McGrath, who had previously found a link between low vitamin D in neo-natal blood and an increased risk of schizophrenia.

“Just as taking folate in pregnancy has reduced the incidence of spina bifida, the result of this study suggests that prenatal Vitamin D supplements may reduce the incidence of autism.

“It’s feasible that a safe, inexpensive, and publicly accessible vitamin D supplement in at-risk groups may reduce the prevalence of this risk factor.”

Protection conferred by vitamin D

Dr Eva Morales of the Center for Research in Environmental Epidemiology in Spain measured vitamin D levels in 1,820 pregnant women. When the infants were 14 months of age, neurocognitive and psychomotor testing revealed that mothers with vitamin D blood levels above 40 ng/ml had infants with the best developed brains.

That level of vitamin D in the blood implies a vitamin D intake of at least 25 mcg or 1,000 IU a day. The northern hemisphere average intake is 6 times less – 4 mcg or 150 IU a day.

Another study in Pediatrics found a strong association between maternal vitamin D deficiency and reduced language development in the child.

D supplements can help children with autism

Vitamin D supplementation may even help children who already have the condition. The Journal of Child Psychology and Psychiatry reported in 2016 that 109 children with autism spectrum disorder were randomised to receive four months of vitamin D3 supplementation or a placebo.

Dr Khaled Saad, lead author of the study, stated:

“Autism symptoms – such as hyperactivity, social withdrawal, and others – improved significantly following vitamin D3 supplementation but not after receiving placebo.”

Vitamin D is now the most common nutritional deficiency in both children and adults, with the British Medical Journal estimating that at least 50% of children are deficient.

By deficient they mean below the UK Recommended Daily Allowance RDA for vitamin D. But that is just 5 mcg or 200 IU – far below the level that key vitamin D researchers are saying is optimal.

How vitamin D may reduce autism and abnormal brain development

Autism linked to vitamin D deficiency NutriShield Multi Vitamins and MineralsMaternal vitamin D depletion can impair the expression of critical growth factors in developing brain tissue.

Foetal brain cells multiply at an astonishing rate during pregnancy. By birth, a baby will have 100 billion brain cells. Each one of these can communicate with up to 15,000 other cells but if these connections are compromised, neurologic disorders, such as autism and even multiple sclerosis (MS), can develop.

Bruce Ames is a highly respected professor of biochemistry and molecular biology at the University of California, Berkeley. Using the University of California’s genome database, he identified three genes that are abnormally expressed in autism and then showed, for the first time, that these genes are responsive to regulation by vitamin D.

Serotonin (and oestrogen producing a serotonin precursor)

One of the key findings of this work was that vitamin D increases production of serotonin in the brain. Serotonin is a brain chemical (neurotransmitter) involved in the regulation of mood, appetite, sleep, and memory. It’s also necessary for normal brain development.

A shortage of serotonin can lead to many of the classic symptoms of autism. They include reduced impulse control and ability to develop socialisation skills.

Fascinatingly, Dr Ames’s work may also explain why autism is 5 times more prevalent in boys than girls. The female sex hormone oestrogen is known to increase the production of a precursor to serotonin. So girls’ brains, with higher levels of serotonin, may be better protected from the adverse effects of vitamin D deficiency, while boys’ brains are more vulnerable.

Oxytocin

In yet another insight, the Ames research indicates that low levels of vitamin D may lead to low production of oxytocin – the so-called ‘love hormone’. Oxytocin is, of course, known to play an important part in socialisation and bonding. Indeed, when adults with autism were given oxytocin, their ability to socialise improved.

Enough vitamin D in pregnancy is vital

In light of these new findings linking lack of vitamin D to autism, it’s vital that pregnant women and children get enough of the nutrient. Indeed the American College of Obstetricians and Gynaecologists now recommends that pregnant women use 1,000 – 2,000 IU of vitamin D, instead of the 400 IU currently present in most “prenatal vitamins”. However, all pregnant women should consult with their own doctors before supplementation.


Vitamin D is important to everybody’s health. Besides autism, vitamin D deficiency is linked to cancer, diabetes, heart disease, arthritis, low immune function and osteoporosis.

For a full free report on the vital role of vitamin D go here now. https://nutrishield.com/the-products/vitamin-d/

And if anyone in your family might plan for a baby sometime in the future, do make them aware of this important new research.

 


If you enjoyed this article, please share it with family and friends. You can follow us on Facebook or Twitter for daily headline health tweets.

Autism linked to vitamin D deficiency NutriShield Multi Vitamins and MineralsAutism linked to vitamin D deficiency NutriShield Multi Vitamins and MineralsAutism linked to vitamin D deficiency NutriShield Multi Vitamins and Minerals

Autism linked to vitamin D deficiency NutriShield Multi Vitamins and MineralsAnd register now for a free monthly e-newsletter on the latest in nutrition and health research.


YAutism linked to vitamin D deficiency NutriShield Multi Vitamins and Mineralsou can buy Vitamin D3 (the preferred form of natural Vitamin D) from here. Our special introductory offer is for 1 bottle of 120 capsules of 2,000IU D3 free when you buy 2.


Dr Paul Clayton designed NutriShield as a comprehensive healthAutism linked to vitamin D deficiency NutriShield Multi Vitamins and Minerals supplement with OPTIMUM levels of essential nutrients. See more detail elsewhere on this site or click on the button.


Autism linked to vitamin D deficiency NutriShield Multi Vitamins and MineralsDr Paul Clayton’s best-selling book Health Defence is available from most good bookstores.

See the website www.healthdefence.com for excerpts and links to buy direct from the publisher.


See online here for delicious recipes from the Health Defence Cookbook  incorporating healthy foods featuring in a Mediterranean Diet. Autism linked to vitamin D deficiency NutriShield Multi Vitamins and Minerals


References:

http://www.cam-mag.com Solving autism-vitamin-d-and-serotonin-synthesis

https://www.ncbi.nlm.nih.gov/pubmed/21664981

The NHS Information Centre, Community and Mental Health Team, Brugha, T. et al (2012). Estimating the prevalence of autism spectrum conditions in adults: extending the 2007 Adult Psychiatric Morbidity Survey. Leeds: NHS Information Centre for Health and Social Care

Morales E, Guxens M, Llop S, Rodríguez-Bernal CL, Tardón A, Riaño I, Ibarluzea J, Lertxundi N, Espada M, Rodriguez A, Sunyer J; on behalf of the INMA Project. Circulating 25-Hydroxyvitamin D3 in Pregnancy and Infant Neuropsychological Development. Pediatrics. 2012 Sep 17.

Whitehouse AJ, Holt BJ, Serralha M, Holt PG, Kusel MM, Hart PH. Maternal serum vitamin D levels during pregnancy and offspring neurocognitive development. Pediatrics. 2012 Mar;129(3):485-93.

McCann JC, Ames BN (2008) Review Article: Is there convincing biological or behavioral evidence linking vitamin D deficiency to brain dysfunction? FASEB J. 22: 982-1001.